Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00302

Target Information
NameSqualene monooxygenase    
Type of targetSuccessful target    
SynonymsERG1    
Oxidosqaulene cyclase    
SE    
Squalene epoxidase    
DiseaseFungal diseases
[ICD9: 110-118   ICD10: B35-B49]
[1]
Hypercholesterolemia
[ICD9: 272.0   ICD10: E78.0]
[2]
Drug(s)ButenafineApprovedDermatologic infections[3]
NaftifineApprovedFungal infections[4][5]
TerbinafineApprovedFungal infections[1][6][4]
TolnaftateApprovedJock itch, athlete's foot [7][4]
BioChemical ClassOxidoreductases acting on paired donors    
EC NumberEC 1.14.99.7
PathwayBiosynthesis of steroids
Metabolic pathways
Terpenoid biosynthesis
UniProt IDP32476
Q14534
FunctionCatalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.    
SequenceMSAVNVAPELINADNTITYDAIVIGAGVIGPCVATGLARKGKKVLIVERDWAMPDRIVGE LMQPGGVRALRSLGMIQSINNIEAYPVTGYTVFFNGEQVDIPYPYKADIPKVEKLKDLVK DGNDKVLEDSTIHIKDYEDDERERGVAFVHGRFLNNLRNITAQEPNVTRVQGNCIEILKD EKNEVVGAKVDIDGRGKVEFKAHLTFICDGIFSRFRKELHPDHVPTVGSSFVGMSLFNAK NPAPMHGHVILGSDHMPILVYQISPEETRILCAYNSPKVPADIKSWMIKDVQPFIPKSLR PSFDEAVSQGKFRAMPNSYLPARQNDVTGMCVIGDALNMRHPLTGGGMTVGLHDVVLLIK KIGDLDFSDREKVLDELLDYHFERKSYDSVINVLSVALYSLFAADSDNLKALQKGCFKYF QRGGDCVNKPVEFLSGVLPKPLQLTRVFFAVAFYTIYLNMEERGFLGLPMALLEGIMILI TAIRVFTPFLFGELIG
Target ValidationClick to Find Target Validation Information.    
Inhibitor1 (beta)-O-galloylpedunculagin[8]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose[8]
1,2,6-tri-O-galloyl-beta-D-glucose[8]
Allylamines[9]
Butenafine[3]
CORILAGIN[8]
ELLAGIC ACID[8]
EPIGALOCATECHIN GALLATE[8]
ETHYLGALLATE[8]
EUGENIIN[8]
FUROSIN[8]
GERANIIN[8]
Green tea[2]
NB-598[2]
Naftifine[4][5]
OCTYL_GALLATE[8]
PEDUNCULAGIN[8]
THEASINENSIN A[8]
Tellurium[2]
Terbinafine[1][6][4]
Thiocarbamate[4]
Tolnaftate[7][4]
Trisnorsqualene difluoromethylidene[8]
chebulinic acid[8]
mallotinic acid[8]
mallotusinic acid[8]
n-cetylgallate[8]
n-dodecylgallate[8]
procyanidin B-2 3,3'-di-O-gallate[8]
sanguiin H-6[8]
trisnorsqualene alcohol[8]
trisnorsqualene cyclopropylamine[8]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus. Antimicrob Agents Chemother. 2004 Jul;48(7):2490-6. To Reference
Ref 2Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50. To Reference
Ref 3Clinical Trichophyton rubrum strain exhibiting primary resistance to terbinafine. Antimicrob Agents Chemother. 2003 Jan;47(1):82-6. To Reference
Ref 4Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7. To Reference
Ref 5Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9. To Reference
Ref 6Molecular mechanism of terbinafine resistance in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2003 Dec;47(12):3890-900. To Reference
Ref 7Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. To Reference
Ref 8J Nat Prod. 2001 Aug;64(8):1010-4.Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. To Reference
Ref 9Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine. Arch Biochem Biophys. 1997 Apr 15;340(2):265-9. To Reference



 

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