Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00361

Target Information
NameAromatic-L-amino-acid decarboxylase    
Type of targetSuccessful target    
SynonymsAADC    
DDC    
DOPA decarboxylase    
DiseaseParkinson's disease
[ICD9: 332   ICD10: F02.3, G20]
[1]
Drug(s)CarbidopaApprovedParkinson's disease[1]
Vitamin B6ApprovedVitamin B6 deficiency[2]
PatromePhase IIIParkinson's disease
BioChemical ClassCarbon-carbon lyases    
EC NumberEC 4.1.1.28
PathwayAlkaloid biosynthesis I
Histidine metabolism
Metabolic pathways
Phenylalanine metabolism
Tryptophan metabolism
Tyrosine metabolism
UniProt IDP20711
FunctionCatalyzes the decarboxylation of l-3,4- dihydroxyphenylalanine (dopa) to dopamine, l-5-hydroxytryptophan to serotonin and l-tryptophan to tryptamine.    
SequenceMNASEFRRRGKEMVDYVANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDV EKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMD WLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQAASPELTQAAIM EKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRASALQEALERDKAAGLIPFFMV ATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN PHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHWQIPLGRRFRSL KMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVN EALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAERE
Target ValidationClick to Find Target Validation Information.    
InhibitorBenserazide[1]
Carbidopa[1]
ActivatorNoradrenalone (arterenone)[3]
CofactorVitamin B6[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22. To Reference
Ref 2Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):1-4. To Reference
Ref 3Activation of an adrenergic pro-drug through sequential stereoselective action of tandem target enzymes. Biochem Biophys Res Commun. 1992 Nov 30;189(1):33-9. To Reference



 

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