Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00374

Target Information
NameBenzodiazepine receptor    
Type of targetSuccessful target    
DiseaseAnxiety disorder, unspecified
[ICD9: 300   ICD10: F40-F42]
[1]
Disorders of initiating and maintaining sleep [insomnias]
[ICD9: 710.0   ICD10: M32]
[2]
Sleeping sickness[2]
Drug(s)AlprazolamApprovedAnxiety disorder[3][4]
ChlordiazepoxideApprovedAnxiety disorder[5][6]
ClorazepateApprovedAnxiety disorder and insomnia[7]
ClotiazepamApprovedAnxiety disorder[8]
EstazolamApprovedInsomnia[9][10]
EszopicloneApprovedInsomnia[11][4]
FludiazepamApprovedAnxiety disorder[12]
FlunitrazepamApprovedInsomnia[3]
FlurazepamApprovedInsomnia[13]
LorazepamApprovedAnxiety disorder[14]
MidazolamApprovedSedation[15]
OxazepamApprovedAnxiety disorder[16]
TemazepamApprovedInsomnia[17]
TriazolamApprovedInsomnia[5][4]
BioChemical ClassTransmembrane protein    
PathwayNeuroactive ligand-receptor interaction
QSAR ModelClick to Find Target QSAR Model.    
AgonistAlprazolam[3][4]
Chlordiazepoxide[5][6]
Clorazepate[7]
Clotiazepam[8]
Diazemuls[18]
Estazolam[9][10]
Eszopiclone[11][4]
Fludiazepam[12]
Flunitrazepam[3]
Flurazepam[13]
Lorazepam[14]
Midazolam[15]
Oxazepam[16]
Temazepam[17]
Triazolam[5][4]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates. J Pharmacol Exp Ther. 2006 Jan;316(1):410-22. Epub 2005 Sep 23. To Reference
Ref 2Insomnias : II. Pharmacological and psychotherapeutic treatment options.. Nervenarzt. 2009 Jun 10. Epub ahead of print. To Reference
Ref 3Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. To Reference
Ref 4Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. To Reference
Ref 5Contribution of alpha1 subunit-containing gamma-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys. Psychopharmacology (Berl). 2009 Apr;203(3):539-46. Epub 2008 Nov 25. To Reference
Ref 6Effects of chlordiazepoxide (Librium) during pregnancy and lactation. Conn Med. 2003 May;67(5):259-62. To Reference
Ref 7Flumazenil-sensitive dose-related physical dependence in planarians produced by two benzodiazepine and one non-benzodiazepine benzodiazepine-receptor agonists. Eur J Pharmacol. 2007 Jun 14;564(1-3):88-93. Epub 2007 Feb 16. To Reference
Ref 8Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40. To Reference
Ref 9Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3126-9. To Reference
Ref 10Design and synthesis of 4H-3-(2-phenoxy)phenyl-1,2,4-triazole derivatives as benzodiazepine receptor agonists. Bioorg Med Chem. 2003 Mar 6;11(5):769-73. To Reference
Ref 11New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9. To Reference
Ref 12Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity. Life Sci. 1985 Jan 14;36(2):113-9. To Reference
Ref 13An epigenetic intervention interacts with genetic strain differences to modulate the stress-induced reduction of flurazepam's antiseizure efficacy in the mouse. Eur Neuropsychopharmacol. 2009 Jun;19(6):398-401. Epub 2009 Feb 1. To Reference
Ref 14Differing effects of intracortical circuits on plasticity. Exp Brain Res. 2009 Mar;193(4):555-63. Epub 2008 Dec 2. To Reference
Ref 15A comparative study on the effects of the benzodiazepine midazolam and the dopamine agents, apomorphine and sulpiride, on rat behavior in the two-way avoidance test. Pharmacol Biochem Behav. 2009 Apr;92(2):351-6. To Reference
Ref 16Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9. Epub 2008 Jul 19. To Reference
Ref 17Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. J Mass Spectrom. 2004 Aug;39(8):856-72. To Reference
Ref 18The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. J Neurochem. 2009 Jul;110(1):244-54. Epub 2009 Apr 27. To Reference



 

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