Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00397

Target Information
NamePancreatic alpha-amylase    
Type of targetSuccessful target    
Synonyms1,4-alpha-D-glucan glucanohydrolase    
AMY2A    
PA    
DiseaseHypoglycemia
[ICD9: 250.8, 251.0, 251.1, 251.2, 270.3, 775.6, 962.3   ICD10: E16.0-E16.2]
[1]
Pancreatic disease[2]
BioChemical ClassGlycosylases    
EC NumberEC 3.2.1.1
PathwayMetabolic pathways
Starch and sucrose metabolism
UniProt IDP04746
PDB Structure1KBK; 1KGU; 1KGW; 1KGX; 1U2Y; 1U30; 1U33; 1XCW.    
SequenceMKFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP NENVAIYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGL LDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNSNWFPAG SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG FVPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP RQFQNGNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNVVDGQP FTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYCDVISGDKINGNCTGI KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
Inhibitor4,6-Dideoxy-4-Amino-Alpha-D-Glucose[3]
5-Hydroxymethyl-Chonduritol[3]
6-Deoxy-Alpha-D-Glucose[3]
Acarbose Derived Hexasaccharide[3]
Acarviostatin III03[2]
Acarviostatin IV03[2]
Alpha-acarviosinyl- (1-->7)-3-alpha-D-glucopyranosylpropen[1]
Alpha-acarviosinyl- (1-->9)-3-alpha-D-glucopyranosylpropen[1]
Beta-D-Glucose[3]
Hydroxycitric acid[4]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam[5]
Pyroglutamic Acid[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30. Epub 2008 Jun 14. To Reference
Ref 2Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92. Epub 2008 Jan 26. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 4Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82. Epub 2007 May 3. To Reference
Ref 5Nucleic Acids Res. 2011 January; 39(Database issue): D1035¨CD1041. DrugBank 3.0: a comprehensive resource for ¡®Omics¡¯ research on drugs To Reference



 

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