Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00419

Target Information
NameCytochrome P450 11A1, mitochondrial    
Type of targetSuccessful target    
SynonymsCYP11A    
CYP11A1    
CYPXIA1    
Cholesterol desmolase    
Cytochrome P450 11A1    
P450(scc)    
DiseaseAdrenocortical tumour
[ICD9: 140-199, 210-229   ICD10: C00-C75, C7A, C7B, D10-D36, D3A]
[1]
Cushing's syndrome
[ICD9: 255.0   ICD10: E24]
[1]
Drug(s)AminoglutethimideApprovedCushing's syndrome and metastatic breast cancer[2]
BioChemical ClassOxidoreductases acting on paired donors    
EC NumberEC 1.14.15.6
PathwayC21-Steroid hormone metabolism
Metabolic pathways
UniProt IDP05108
SequenceMLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
Inhibitor3- (4-Amino-phenyl)-3-butyl-piperidine-2,6-dione[3]
3- (4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione[3]
Aminoglutethimide[2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29. To Reference
Ref 2Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15. To Reference
Ref 3J Med Chem. 1986 Aug;29(8):1362-9.Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. To Reference



 

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