Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00450

Target Information
NameMannose-6-phosphate isomerase    
Type of targetSuccessful target    
SynonymsPMI    
Phosphohexomutase    
Phosphomannose isomerase    
DiseaseFungal diseases
[ICD9: 110-118   ICD10: B35-B49]
[1][2]
Drug(s)SulfacetamideApprovedBacterial infections[3]
SulfanilamideApprovedBacterial infections[3]
SulfoxoneApprovedBacterial infections[3]
BioChemical ClassIntramolecular oxidoreductases    
EC NumberEC 5.3.1.8
PathwayAmino sugar and nucleotide sugar metabolism
Fructose and mannose metabolism
Metabolic pathways
UniProt IDP00946
P34948
P34949
PDB Structure1PMI.    
FunctionInvolved in the synthesis of the gdp-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.    
SequenceMSSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSK AIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGA QLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEF ISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDS RLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASD NVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSV LQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIE LTADSANQDQDFTTYRAFVEA
Target ValidationClick to Find Target Validation Information.    
InhibitorAcetate Ion[4]
Formic Acid[4]
GNF-PF-2272[5]
GNF-PF-5134[5]
NSC-66209[5]
Sulfacetamide[3]
Sulfanilamide[3]
Sulfoxone[3]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution. Nat Struct Biol. 1996 May;3(5):470-9. To Reference
Ref 2Identification and characterization of the Cryptococcus neoformans phosphomannose isomerase-encoding gene, MAN1, and its impact on pathogenicity. Mol Microbiol. 2001 May;40(3):610-20. To Reference
Ref 3Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54. To Reference
Ref 4Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference
Ref 5Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). To Reference



 

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