Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00462

Target Information
NameBacterial outer membrane    
Type of targetSuccessful target    
DiseaseBacterial infections
[ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104   ICD10: A00-A09, A15-A19, A20-A28, A30-A49, A65-A69, A70-A74, A75-A79]
[1]
Drug(s)CandicidinApprovedBacterial infections[2]
ChlorhexidineApprovedBacterial infections[3]
ColistimethateApprovedBacterial infections[4]
ColistinApprovedBacterial infections[4]
DaptomycinApprovedBacterial infections[5]
Gramicidin DApprovedBacterial infections[6]
Polymyxin B SulfateApprovedBacterial infections[4]
Silver sulfadiazineApprovedBacterial infections[1]
VancomycinApprovedBacterial infections[7]
CefozopranLaunchedGram-positive excluding Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus and -negative including P. aeruginosa[8]
FaropenemLaunchedGram-positive excluding Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus and -negative including P. aeruginosa[8]
DoripenemPhase IIIGram-positive excluding Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus and -negative including P. aeruginosa[8]
SUN13834Phase II completedGram-positive and -negative bacterial infections including P. aeruginosa[8]
OritavancinNon-approval letter from FDAGram-positive bacterial infections including MRSA or VRE[8]
Target ValidationClick to Find Target Validation Information.    
InhibitorCefozopran[8]
Doripenem[8]
Ethylene diamine[9]
Faropenem[8]
HKI-9924129[8]
Oritavancin[8]
SUN13834[8]
BreakerChlorhexidine[3]
BinderCandicidin[2]
Colistimethate[4]
Colistin[4]
Daptomycin[5]
Gramicidin D[6]
Polymyxin B Sulfate[4]
Silver sulfadiazine[1]
Vancomycin[7]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Comparative evaluation of transdermal formulations of norfloxacin with silver sulfadiazine cream, USP, for burn wound healing property. J Burns Wounds. 2006 Jun 7;5:e4. To Reference
Ref 2Polyene antibiotics increase the ionic permeability of synaptosomal plasma membranes. Biochem Pharmacol. 1991 May 1;41(9):1345-50. To Reference
Ref 3The mechanism of action of chlorhexidine. FEMS Microbiol Lett. 1992 Dec 15;79(1-3):211-5. To Reference
Ref 4Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7. To Reference
Ref 5Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57. To Reference
Ref 6Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86. To Reference
Ref 7Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3721-4. Epub 2009 May 24. To Reference
Ref 8Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. To Reference
Ref 9Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. To Reference



 

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