Therapeutic Targets Database
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TTD Target ID: TTDS00476

Target Information
NameIndoleamine 2,3-dioxygenase    
Type of targetSuccessful target    
Synonyms INDO    
IDO    
Indoleamine-pyrrole 2,3-dioxygenase    
DiseaseDepression
[ICD9: 311   ICD10: F32]
[1]
Drug(s)L-TryptophanApprovedDepression[1]
INCB24360Phase IOncology[2]
BioChemical ClassOxidoreductases acting on single donors    
EC NumberEC 1.13.11.52
PathwayMetabolic pathways
UniProt IDP14902
PDB Structure2D0T; 2D0U.    
FunctionCatalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.    
SequenceMAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Target ValidationClick to Find Target Validation Information.    
Inhibitor1,2-NAPHTHOQUINONE[3]
1,4-naphtho-quinone[3]
1-methyltryptophan[4]
1H-indole-4,7-dione[5]
2,2-dimethyl-2H-benzo[g]chromene-5,10-dione[3]
2,3-dichloro-1,4-naphthoquinone[3]
2,3-dihydrobenzo[d]thiazole-2-thiol[6]
2,4-Dichlorobenzenemethanethiol[7]
2- (1H-Imidazol-4-yl)benzene-1,3-diol[8]
2- (1H-Imidazol-4-yl)phenol[8]
2-Chlorobenzenemethanethiol[7]
2-HYDROXYGARVIN A[4]
2-hydroxygarveatin E[4]
2-methoxy-1,4-naphthoquinone[3]
3,4-Dichlorobenzenemethanethiol[7]
3- (1H-Imidazol-4-yl)benzenethiol[8]
3- (4H-Imidazol-4-yl)benzenethiol[8]
4- (1H-1,2,3-triazol-5-yl)pyridine[6]
4- (2-[6]
4- (2-Hydroxyethoxy)-1-naphthol[6]
4- (Benzylamino)-1-naphthol[6]
4- (Cyclohexylamino)-1-naphthol[6]
4- (Isopropylamino)-1-naphthol[6]
4- (Pent-3-ylamino)-1-naphthol[6]
4- (ethylamino)naphthalen-1-ol[6]
4- (methylamino)naphthalen-1-ol[6]
4- (propylamino)naphthalen-1-ol[6]
4- (tert-butylamino)naphthalen-1-ol[6]
4-Chlorobenzenemethanethiol[7]
4-Fluorobenzenemethanethiol[7]
4-Methoxybenzenemethanethiol[7]
4-Methylbenzenemethanethiol[7]
4-Phenylimidazole[8]
4-amino-1,2,5-oxadiazole-3-carboximidamide[9]
4-aminonaphthalen-1-ol[6]
4-methoxynaphthalen-1-amine[6]
4-phenylthiazole-2-thiol[6]
5- (isopropylamino)quinolin-8-ol[6]
5-aminoquinolin-8-ol[6]
5-phenyl-1H-1,2,3-triazole[6]
ANNULIN A[4]
ANNULIN B[4]
ANNULIN C[4]
BENZENEMETHANETHIOL[7]
EXIGUAMINE B[10]
Exiguamine A[5]
Exiguamine A hydrochloride[10]
GARVEATIN A[4]
INCB24360[2]
JUGLONE[3]
N-[2- (Indol-3-yl)ethyl]-S-benzyl-dithiocarbamate[11]
S- (2,4-Dichlorobenzyl)isothiourea hydrobromide[7]
S- (2-Chlorobenzyl)isothiourea hydrochloride[7]
S- (3,4-Dichlorobenzyl)isothiourea hydrochloride[7]
S- (3-Chlorobenzyl)isothiourea hydrochloride[7]
S- (4-Bromobenzyl)isothiourea hydrobromide[7]
S- (4-Chlorobenzyl)isothiourea hydrochloride[7]
S- (4-Cyanobenzyl)isothiourea hydrobromide[7]
S- (4-Ethylbenzyl)isothiourea hydrochloride[7]
S- (4-Fluorobenzyl)isothiourea hydrochloride[7]
S- (4-Methoxybenzyl)isothiourea hydrochloride[7]
S- (4-Methylbenzyl)isothiourea hydrochloride[7]
S- (4-Nitrobenzyl)isothiourea hydrochloride[7]
S-Benzyl-brassinin[11]
Seco-exiguamine[10]
garveatin C[4]
garveatin E[4]
naphthalene-1,4-diol[6]
BinderL-Tryptophan[1]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38. To Reference
Ref 2Incyte. Product Development Pipeline. 2009. To Reference
Ref 3J Med Chem. 2008 Mar 27;51(6):1706-18. Epub 2008 Mar 5.Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. To Reference
Ref 4J Nat Prod. 2006 Oct;69(10):1496-9.Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. To Reference
Ref 5J Med Chem. 2008 May 8;51(9):2634-7. Epub 2008 Apr 8.Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A. To Reference
Ref 6J Med Chem. 2010 Feb 11;53(3):1172-89.Rational design of indoleamine 2,3-dioxygenase inhibitors. To Reference
Ref 7Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. Epub 2010 Jul 11.S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. To Reference
Ref 8J Med Chem. 2008 Aug 28;51(16):4968-77. Epub 2008 Jul 30.Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. To Reference
Ref 9J Med Chem. 2009 Dec 10;52(23):7364-7.Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. To Reference
Ref 10Nat Chem Biol. 2008 Sep;4(9):535-7.Biomimetic synthesis of the IDO inhibitors exiguamine A and B. To Reference
Ref 11J Med Chem. 2006 Jan 26;49(2):684-92.Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. To Reference



 

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