Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
   

 

TTD Target ID: TTDS00494

Target Information
NameBiliverdin reductase A    
Type of targetSuccessful target    
SynonymsBLVR    
BLVRA    
BVR    
BVR A    
Biliverdin-IX alpha-reductase    
DiseasePrimary biliary cirrhosis
[ICD9: 571.6   ICD10: K74.3]
[1][2]
Drug(s)Ursodeoxycholic acidApprovedPrimary biliary cirrhosis[1][2]
BioChemical ClassOxidoreductases acting on the CH-CH group of donors    
EC NumberEC 1.3.1.24
UniProt IDP53004
PDB Structure2H63.    
FunctionReduces the gamma-methene bridge of the open tetrapyrrole, biliverdin ix alpha, to bilirubin with the concomitant oxidation of a nadh or nadph cofactor.    
SequenceMNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLE DALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKV LHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLF GELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLEN VPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
InhibitorNicotinamide-Adenine-Dinucleotide[3]
ActivatorUrsodeoxycholic acid[1][2]
Cross References 3D Structure
Related Literature
On-Line Medical Dictionary
Ref 1Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36. Epub 2008 Jul 23. To Reference
Ref 2Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7. To Reference
Ref 3Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. To Reference



 

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