Therapeutic Target Database
to provide information about the known and explored therapeutic
protein and nucleic acid targets, the targeted disease, pathway
information and the corresponding drugs directed at each of these
targets. Also included in this database are links to relevant
databases containing information about target function, sequence,
3D structure, ligand binding properties, enzyme nomenclature and
drug structure, therapeutic class, clinical development status.
All information provided are fully referenced.
Statistics of this database
database currently contains 2,360
targets, including 388
successful, 461 clinical
trial, 44 discontinued
and 1,331 research targets,
drugs, including 2,003
approved, 3,147 clinical
trial, 14,853 experimental
drugs (14,170 small molecules and 652
antisense drugs with available strucuture or oligonucleotide sequence).
The database incorporates the ICD-10-CM and ICD-9-CM codes of the International Classification of Diseases (covering 897 disease conditions, 893 targets, and 5,697 drugs), and also contains biomarkers (1,755 biomarkers for 365 disease conditions), drug scaffolds (210 scaffolds for 714 drugs and leads), 1,008 nature-derived agents, 20818 multi-target agents against 385 target-pairs, and the activity data of 1,436 agents against 297 cell-lines.
How to cite our database
Qin C, Zhang C, Zhu F, Xu F, Chen SY, Zhang P, Li YH, Yang SY, Wei YQ, Tao L, Chen YZ. Therapeutic target database update 2014: a resource for targeted therapeutics. Nucleic Acids Res. 42(Database issue): D1118-23, 2014. PubMed.
Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, Zhang L, Song Y, Liu XH, Zhang JX, Han BC, Zhang P, Chen YZ. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 40(D1): D1128-1136, 2012. PubMed.
Han BC, Pankaj Kumar, Liu XH, Ma XH, Wei XN, Huang L, Guo YF,
Han LY, Zheng CJ, Chen YZ. Update of TTD: Therapeutic Target Database.
Acids Res. 38(suppl
1):D787-91, 2010. PubMed
X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic
Acids Res. 30(1):412-415,
Last update by
Sep 15th, 2013
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Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
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