Therapeutic Targets Database
BIDD Pharmainformatics Databases

  Due to hardware problems, TTD access may be slow. For the time being we are trying to fix the problem as soon as we can. Please accept our apology for the inconvenience caused.

  We are experiencing a severe shortage of funding. If you like TTD, we hope you can write to the following funding agencies to suggest them to support us.

  Office of Deputy President (Research & Technology), National University of Singapore []

  National Research Foundation, Singapore []

  Thanks for your support!

  For accessing the TTD 2016, you can go to:



Search Whole Database

Search drugs and targets by disease or ICD identifier: ICD9 Index ICD10 Index

Examples: Alzheimer; 331 or ICD9:331; G30 or ICD10:G30; ...

Search for drugs:

Examples: Oseltamivir; Alzheimer's disease; ...

Search for targets:

Examples: Muscarinic acetylcholine receptor; Non-small cell lung cancer; ...

Search for biomarkers: ICD9 Index ICD10 Index

Examples: p53; Alzheimer; 331 or ICD9:331; G30 or ICD10:G30; ...

Search for drug scaffolds:

Read more about TTD Query Methods


Therapeutic Target Database

A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. Also included in this database are links to relevant databases containing information about target function, sequence, 3D structure, ligand binding properties, enzyme nomenclature and drug structure, therapeutic class, clinical development status. All information provided are fully referenced.

Statistics of this database

This database currently contains 2,360 targets, including 388 successful, 461 clinical trial, 44 discontinued and 1,331 research targets, 20,667 drugs, including 2,003 approved, 3,147 clinical trial, 14,853 experimental drugs (14,170 small molecules and 652 antisense drugs with available strucuture or oligonucleotide sequence).

The database incorporates the ICD-10-CM and ICD-9-CM codes of the International Classification of Diseases (covering 897 disease conditions, 893 targets, and 5,697 drugs), and also contains biomarkers (1,755 biomarkers for 365 disease conditions), drug scaffolds (210 scaffolds for 714 drugs and leads), 1,008 nature-derived agents, 20818 multi-target agents against 385 target-pairs, and the activity data of 1,436 agents against 297 cell-lines. .

How to cite our database

Qin C, Zhang C, Zhu F, Xu F, Chen SY, Zhang P, Li YH, Yang SY, Wei YQ, Tao L, Chen YZ. Therapeutic target database update 2014: a resource for targeted therapeutics. Nucleic Acids Res. 42(Database issue): D1118-23, 2014. PubMed.

Zhu F, Shi Z, Qin C, Tao L, Liu X, Xu F, Zhang L, Song Y, Liu XH, Zhang JX, Han BC, Zhang P, Chen YZ. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 40(D1): D1128-1136, 2012. PubMed.

Zhu F, Han BC, Pankaj Kumar, Liu XH, Ma XH, Wei XN, Huang L, Guo YF, Han LY, Zheng CJ, Chen YZ. Update of TTD: Therapeutic Target Database. Nucleic Acids Res. 38(suppl 1):D787-91, 2010. PubMed

Chen X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic Acids Res. 30(1):412-415, 2002. PubMed

Last update by

Sep 15th, 2013


visits since 2002 .........


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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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