Therapeutic Targets Database
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TTD Drug ID: DAP000088

Drug Information
NameTimolol    
SynonymsBetimol; NCGC00016038-01; (2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; Timacar; C07141; MK-950; AB00513729; Istalol; SAM002564238; Tenopt; Prestwick3_000948; Prestwick1_000948; DB08625; Timoptic-XE; Tim-AK; Timololum; (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole; Proflax; S(-)-Timolol maleate; Optimol; TIM; Prestwick2_000948; HSDB 6533; Tocris-0649; LS-122231; Timolol [USAN]; Timolol (INN); Lopac-T-6394; BPBio1_001008; HMS2089I11; 26921-17-5 (maleate (1:1) salt); Timoptol; Prestwick0_000948; NCGC00022033-04; CHEMBL499; Timolol GFS; BSPBio_000916; L-714,465; Blocadren; Timopic; Oprea1_640981; 26839-75-8; ST072193; NCGC00022033-05; (S)-timolol; DB00373; timolol; Betimol (TN); BRD-K08806317-050-03-6; Phoxal-timolol; NCGC00016798-07; CID33624; Timololum [INN-Latin]; Temserin; NCGC00016798-01; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; Apo-Timop; CHEBI:9599; Timolol (TN); NCGC00016038-02; (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; Timolol Maleate, (1:1) Salt; 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (2S)-; Timoptic OcuDose; D08600; Lopac0_001189; EINECS 248-032-6; 194288-09-0; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; C13H24N4O3S; UNII-817W3C6175; NCGC00022033-02; (2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; Aquanil; CAS-26921-17-5; AC1Q59QM; Apo-Timol; BIDD:GT0073; Betim; Novo-Timol; SPBio_003075; 131628-37-0; S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole; CPD001456519; AC1L1PYN; Nu-Timolol; 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-    
Trade NameApo-Timol; Apo-Timop; Gen-Timolol; Nu-Timolol; Phoxal-timolol; PMS-Timolol; Tim-AK; Timoptic; Timoptic-XE; Betimol; Blocadren; Istalol; Timoptic; Timoptic-XE; Timoptic OcuDose.    
CompanyMerck Frosst    
IndicationHigh blood pressureApproved    [1]
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
   
Therapeutic ClassAnti-Arrhythmia Agents    
CAS NumberCAS 26839-75-8
FormularC13H24N4O3S    
PubChem Compound IDCID 33624.    
PubChem Substance IDSID 9350.    
ChEBI9599;    
SuperDrug ATC IDC07AA06;    
SuperDrug CAS ID026839758;    
TargetBeta adrenergic receptorAntagonist[2][3][4]
Ref 1Brinzolamide/timolol fixed combination: a new ocular suspension for the treatment of open-angle glaucoma and ocular hypertension. Expert Opin Pharmacother. 2009 Aug;10(12):2015-24. To Reference
Ref 2Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95. To Reference
Ref 3Blockade of beta-adrenergic receptors prevents amphetamine-induced behavioural sensitization in rats: a putative role of the bed nucleus of the stria terminalis. Int J Neuropsychopharmacol. 2005 Dec;8(4):569-81. Epub 2005 Apr 19. To Reference
Ref 4A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects. Br J Clin Pharmacol. 1997 Mar;43(3):301-8. To Reference



 

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