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TTD Drug ID: DAP000145

Drug Information
NameCeftriaxone    
Synonyms(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate; ceftriaxone; 104376-79-6 (di-hydrochloride salt); CTRX; C18H18N8O7S3; Longacef; 104376-79-6; Ceftriaxone, Disodium Salt; Ro 139904; D07659; Ceftriazone; CHEMBL161; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; AC-1592; Ceftriaxonum [INN-Latin]; Ceftriaxona; Ro-13-9904; Ro13-9904; DB01212; Rocephine; Ceftriaxone [USAN:JAN]; CEFTRIAXONE SODIUM; CID5479530; Ceftriaxonum; Ceftriaxone (TN); (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Ceftriaxone (INN); (6R,7R)-7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7^2-(Z)-(O-; AC1NUIFE; CHEBI:29007; 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid; Cefatriaxone; Ceftriaxone intravenous; Rocefin; Ceftriaxon; Longaceph; Biotrakson; LS-150031; Ceftriaxone, Disodium Salt, Hemiheptahydrate; C06683; 74578-69-1 (di-hydrochloride salt, hemiheptahydrate); UNII-75J73V1629; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, (6R,7R)-; Rocephin; EINECS 277-405-6; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio)methyl)-, (6R-(6alpha,7beta(Z)))-; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; DRG-0071; 73384-59-5; MolPort-005-933-495; Ceftriaxona [INN-Spanish]    
Trade NameRocephin    
CompanyHoffmann-La Roche pharmaceutical company    
IndicationBacterial infectionsApproved    [1]
Structure

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Therapeutic ClassAnti-Bacterial Agents    
CAS NumberCAS 73384-59-5
FormularC18H18N8O7S3    
PubChem Compound IDCID 5479530.    
PubChem Substance IDSID 8908.    
SuperDrug ATC IDJ01DD04;    
SuperDrug CAS ID073384595;    
TargetD-alanyl-D-alanine carboxypeptidaseInhibitor[2][3]
Ref 1How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30. To Reference
Ref 2Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307. To Reference
Ref 3Interaction of ceftriaxone with penicillin-binding proteins of Escherichia coli in the presence of human serum albumin. J Antimicrob Chemother. 1998 Jul;42(1):95-8. To Reference



 

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