Therapeutic Targets Database
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TTD Drug ID: DAP000156

Drug Information
NameAtovaquone    
SynonymsAB00513855; Spectrum2_001665; STK636160; Prestwick1_000534; NCGC00016961-02; DivK1c_006782; SPBio_002468; 566C80, hydroxynaphthoquinone; pron; CRL-8131 & Atovaquone; BW 556C-80; Compound 566; ATOVAQUONE; Wellvone; Malarone Pediatric; 1,4-Naphthalenedione, 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-; 2-[trans-4-(p-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone; KBio2_002223; Atovaquone & Interleukin 12; atovaquone GlaxoSmithKline brand; C06835; AC1L2MZG; 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone; Spectrum4_001117; D00236; BSPBio_000547; Mepron (antipneumocystic); HMS1569L09; BW 566C80; BPBio1_000603; KBio2_007359; GlaxoSmithKline brand of atovaquone; 94015-53-9; SPECTRUM1504210; C22H19ClO3; HSDB 7083; SMR001233220; Bio-0115; Atovaquone (USP/INN); 1,4-Naphthalenedione, 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-, trans-; SpecPlus_000686; Mepron (TN); MLS002153863; 2-(4-(4'-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; I06-0872; 566C80; 3-(4-(4-chlorophenyl)cyclohexyl)-4-hydroxy-naphthalene-1,2-dione; D053626; BW 566C; Mepron; KBio2_004791; Glaxo Wellcome brand of atovaquone; 1,4-Naphthalenedione, 2-(4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-, trans-; BW-A 566C; 2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; CHEMBL1450; Spectrum5_001382; Prestwick0_000534; SPBio_001849; BIDD:GT0849; 566C80 hydroxynaphthoquinone; Prestwick2_000534; KBioSS_002223; HMS1922F19; Spectrum_001743; 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione; BW 566C-80; 566C; HMS2093C10; HMS2089M14; 1,4-Naphthalenedione, 2-(4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-; Prestwick3_000534; CHEBI:478315; CAS-95233-18-4; NCGC00095113-02; 2-(trans-4-(p-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; AC1Q6E9K; AC-15237; MolPort-003-666-542; NCGC00016961-01; NCGC00095113-01; BSPBio_002681; hydroxynaphthoquinone 566C80; 95233-18-4; FT-0081084; Atovaquone [USAN:BAN:INN]; DB01117; LS-178256; KBio3_001901; CID74989; KBio1_001726; Atavaquone; 1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-; AR-1H7607; MolPort-003-844-665; 1,4-naphthalenedione,2-(trans-4-(4-chlorophenyl)cyclohexyl)-3-hydroxy-; DRG-0084; CHEBI:575568; 2-(4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone; KBioGR_001594; Spectrum3_000991; ATO & IL-12; 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione; hydroxynaphthoquinone, 566C80; Acuvel; MolPort-006-666-289    
Trade NameMepron    
CompanyGlaxoSmithKline    
IndicationFungal infectionsApproved    [1]
Structure

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Therapeutic ClassAntifungal Agents    
CAS NumberCAS 95233-18-4
FormularC22H19ClO3    
PubChem Compound IDCID 74989.    
PubChem Substance IDSID 9053.    
SuperDrug ATC IDP01AX06;    
SuperDrug CAS ID095233184;    
TargetDihydroorotate dehydrogenase, mitochondrialInhibitor[2][3][4][5]
Ref 1The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. To Reference
Ref 2Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci. 2004 Apr;13(4):1031-42. To Reference
Ref 3Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. Antimicrob Agents Chemother. 2000 Mar;44(3):713-9. To Reference
Ref 4Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. To Reference
Ref 5The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp Parasitol. 1994 Aug;79(1):50-6. To Reference



 

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