TTD Drug ID: DAP000236

Drug Information
Name	Apraclonidine
Synonyms	MolPort-005-933-986; Lopac-A-0779; C07668; 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine; Iopidine Eye; Apraclonidine [INN:BAN]; Iopidine (TN); ZINC00020231; MolPort-003-940-020; Lopac0_000033; CHEBI:2788; Apraclonidina; DB00964; D07461; CHEBI:127495; L013394; 4-Aminoclonidine; C9H10Cl2N4; 2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride; 2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; CID2216; NCGC00015033-03; 1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)-; 66711-21-5; AC1L1D6L; UNII-843CEN85DI; Apraclonidine (INN); ALO 2145; NCGC00162050-01; AC-12697; Apraclonidinum [INN-Latin]; CHEMBL647; PDSP2_000778; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; NCGC00015033-01; SMP1_000016; para-aminoclonidine; Apraclonidinum; LS-176536; apraclonidine; Aplonidine; Iopidine; A0779_SIGMA; PDSP1_000790; Apraclonidina [INN-Spanish]; L000686; p-aminoclonidine
Company	Alcon Canada Inc
Indication	Additional Intra Ocular Pressure (IOP) reduction			Approved    [1]
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
Therapeutic Class	Antiglaucomic Agents
CAS Number	CAS 66711-21-5
Formular	C9H10Cl2N4
PubChem Compound ID	CID 2216.
PubChem Substance ID	SID 9870.
SuperDrug ATC ID	S01EA03;
SuperDrug CAS ID	066711215;
Target	Alpha-2 adrenergic receptor			Agonist	[2][3]
Ref 1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2	Apraclonidine attenuates the increases in spinal excitatory amino acid release in rats with adjuvant-induced inflammation. Anesth Analg. 2002 Mar;94(3):701-5; table of contents. To Reference
Ref 3	Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors. Brain Res. 2001 Jun 15;904(1):126-36. To Reference

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.

Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.