Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DAP000287

Drug Information
NameMecasermin    
Trade NameIncrelex    
IndicationIGF-1 deficiencyApproved    [1]
Therapeutic ClassImmunomodulatory Agents    
CAS NumberCAS 68562-41-4
FormularC331H518N94O101S7    
TargetInsulin-like growth factor I receptorInhibitor[2][3][4][5]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45. Epub 2003 Jul 5. To Reference
Ref 3One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Arthritis Rheum. 2003 May;48(5):1302-14. To Reference
Ref 4Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1113-20. To Reference
Ref 5Insulin-like growth factor I receptor gene structure. J Biol Chem. 1992 May 25;267(15):10759-63. To Reference



 

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