Therapeutic Targets Database
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TTD Drug ID: DAP000322

Drug Information
NameClemastine    
SynonymsNCGC00016710-01; Clemastine [USAN:BAN]; Tavegyl; HS 592; 14976-57-9; Spectrum2_000689; Prestwick2_000306; AC1L1CAE; Clemastina; IDI1_000285; KBio1_000285; NINDS_000285; HMS2089I22; Spectrum3_000353; C21H26ClNO; Prestwick1_000306; (+)-(2R)-2-(2-(((R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine; (2R)-2-(2-{[(1R)-1-(4-chlorophenyl)-1-phenylethyl]oxy}ethyl)-1-methylpyrrolidine; CHEBI:3738; NCGC00015281-01; BSPBio_002045; clemastine; Clemastinum [INN-Latin]; Prestwick0_000306; Mecloprodin; (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine; Meclastine; DB00283; BSPBio_000272; SPBio_000817; (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine; KBioGR_001570; 15686-51-8; Spectrum5_001520; BPBio1_000300; 2(R)-[2-[(1R)-(4-Chlorophenyl)-1-phenyl-ethoxy]ethyl-1-methylpyrrolidine; Clemastinum; Lopac-C-8903; Meclastin; HS-592; (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine; CAS-14976-57-9; UNII-95QN29S1ID; CID26987; BRD-K30240666-051-05-0; AC1Q3N52; CLEMASTINE FUMARATE; BIDD:GT0391; SPBio_002491; CHEMBL1626; Clemastina [INN-Spanish]; Spectrum4_000955; LS-137531; DivK1c_000285; Tavist (*Fumarate*); Tocris-1453; Tavist; 2-(2-(4-Chlor-alpha-methylbenzhydryloxy)ethyl)-1-methylpyrrolidin; NCGC00025168-01; Prestwick3_000306; KBio3_001265    
Trade NameTavist; Tavegyl    
CompanyNorvatis Phamaceuticals Corporation    
IndicationAllergic rhinitisApproved    [1]
Structure

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Therapeutic ClassAnti-Allergic Agents    
CAS NumberCAS 15686-51-8
FormularC21H26ClNO    
PubChem Compound IDCID 26987.    
PubChem Substance IDSID 205033.    
SuperDrug ATC IDD04AA14;    
SuperDrug CAS ID015686518;    
TargetHistamine H1 receptorAntagonist[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 073283 To Reference
Ref 2Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor. J Invest Dermatol. 2008 Dec;128(12):2783-91. Epub 2008 Jun 12. To Reference
Ref 3Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine. Arch Pharm Res. 2007 Dec;30(12):1521-5. To Reference



 

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