Therapeutic Targets Database
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TTD Drug ID: DAP000324

Drug Information
NameHydroxyzine    
SynonymsAtaraxoid; 2192-20-3 (di-hydrochloride); Hydroxyzin; Traquizine; Marex (TN); NP 212; BPBio1_000228; ST059726; 2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol; CHEBI:5818; Atarax base; BRD-A62428732-096-02-6; Hydroxyzine (INN); 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; Idrossizina; Paxistil; MolPort-002-506-318; C21H27ClN2O2; 10246-75-0 (pamoate); D08054; Orgatrax; Idrossizina [DCIT]; 2-[2-[4-(p-Chloro-.alpha.-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol; Hychotine; Hydroksyzyny; HSDB 3098; Hydroxyzinum; Hydroxyzine hydrochloride; DB00557; N-(4-Chlorobenzhydryl)-N'-(hydroxyethyloxyethyl)piperazine; N-(4-Chlorobenzhydryl)-N'-(hydroxyethoxyethyl)piperazine; 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine; BSPBio_000206; Neurozina; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; UCB 4492; 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol; Atarazoid; 1-(p-Chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; Hydroxyzinum [INN-Latin]; AB00053485; EINECS 200-693-1; Hydroksyzyny [Polish]; Prestwick2_000133; WLN: T6N DNTJ AYR&R D6& D2O2Q; hydroxyzine; L000930; Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-; neo-Calma; Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-; Atarox; Durrax; NSC 169188; CID3658; Hydroxyzyne; 68-88-2; Atara; Tranquizine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine; 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethanol; BRN 0321392; U.C.B 4492; LS-66601; U.CB 4492; 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine; Parenteral; 1-(p-Chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine; C07045; NSC169188; AC1L1GFB; UNII-30S50YM8OG; Hy-Pam 25; Plaxidol; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-[2-[(2-hydroxyethoxy)ethyl]piperazine; CHEMBL896; Vesparaz-Wirkstoff; Prestwick0_000133; BRD-A62428732-300-03-0; Atarax; 5-23-01-00462 (Beilstein Handbook Reference); Nevrolaks; Hidroxizina [INN-Spanish]; Hydroxine; Hydroxycine; Placidol; Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)- (9CI); Vistaril; Pamazone; SPBio_002145; 2-[(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]ethanol; Tran-Q; Hydroxyzine Hcl; AKOS003334349; Hidroxizina; Deinait; Prestwick3_000133; Hydroxizine; Atazina; 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol; Hydroxyzine base; Prestwick1_000133; Ethanol, 2-[2-[4-(p-chloro-.alpha.-phenylbenzyl)-1-piperazinyl]ethoxy]-; Fenarol; Hydroxizinum; Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-; Aterax; UCB 492; Hydroxyzine [INN:BAN]    
Trade NameVistaril; Atarax    
CompanyPfizer Pharmaceuticals    
IndicationAnxiety disorderApproved    [1]
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
   
Therapeutic ClassHypnotics and Sedatives    
CAS NumberCAS 68-88-2
FormularC21H27ClN2O2    
PubChem Compound IDCID 3658.    
PubChem Substance IDSID 9257.    
ChEBI5818;    
SuperDrug ATC IDN05BB01;    
SuperDrug CAS ID000068882;    
TargetHistamine H1 receptorAntagonist[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 085551 To Reference
Ref 2Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. J Pharmacol Sci. 2008 Dec;108(4):462-71. Epub 2008 Dec 5. To Reference
Ref 3Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem. 2008;15(21):2173-91. To Reference



 

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