Therapeutic Targets Database
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TTD Drug ID: DAP000332

Drug Information
NameAzelastine    
SynonymsAzelastinum [INN-Latin]; CID2267; L001153; 37932-96-0 (unspecified hydrochloride); DB00972; C07768; Spectrum2_000649; 4-(p-chlorobenzyl)-2-(N-methylperhydroazepinyl-(4))-1-(2H)-phthalazinone; AC1L1DAR; CHEBI:2950; Azelastine (INN); Spectrum3_001984; 4-((4-chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCl; BSPBio_003584; Azelastine [INN:BAN]; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one; 1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-; Azelastina; LS-109214; I14-2736; C22H24ClN3O; NCGC00177979-01; 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone; UNII-ZQI909440X; Optivar (TN); 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone hydrochloride; D07483; 79307-93-0 (hydrochloride); SPBio_000657; BRN 0900747; 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one; Azelastina [INN-Spanish]; BRD-A68888262-003-02-9; Azelastinum; azelastine; CHEMBL639; KBio3_002992; I06-0157; Optivar; 58581-89-8    
Trade NameAstelin; Astepro    
CompanyMeda Pharmaceuticals Inc    
IndicationAllergic conjunctivitisApproved    [1]
Structure

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Therapeutic ClassAnti-Allergic Agents    
CAS NumberCAS 58581-89-8
FormularC22H24ClN3O    
PubChem Compound IDCID 2267.    
PubChem Substance IDSID 9970.    
SuperDrug ATC IDR01AC03;    
SuperDrug CAS ID058581898;    
TargetHistamine H1 receptorAntagonist[2][3]
Ref 1Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. To Reference
Ref 2Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29. To Reference
Ref 3The in vivo potency and selectivity of azelastine as an H1 histamine-receptor antagonist in human airways and skin. J Allergy Clin Immunol. 1988 Dec;82(6):1113-8. To Reference



 

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