Therapeutic Targets Database
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TTD Drug ID: DAP000334

Drug Information
NamePromethazine    
SynonymsPhensedyl; PromethazineHcl; N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine; Isophenergan; KBio1_000005; Promethegan; 3389 R.p.; Promacot; Prestwick2_000888; Prometasin; NSC 30321; AB00053535; Procit; KBio2_001348; Thiergan; Hiberna; 73745-50-3; Dimethylamino-isopropyl-phenthiazin [German]; KBio3_001997; AC1L1J92; Spectrum3_001019; Diprozin; D00494; Promethazin; NCGC00089735-03; Promethaine; NCI60_001878; 60-87-7; Prothazin; DB01069; Promethiazine; Phenargan; KBio2_006484; WY 509; Oprea1_758749; KBioGR_001697; Camergan; HSDB 3173; Prometazina; CHEMBL643; Histargan; Metaryl; Phargan; 4182 R.p.; N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine; KBio2_003916; HMS2089E08; CCRIS 7056; Prestwick1_000888; Genphen; Phenerzine; 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine; AC-15939; Lilly 1516; Diprazin; NCI-C60673; KBioSS_001348; Phenothiazine, 10-[2-(dimethylamino)propyl]-; Vallergine; Prometazina [INN-Spanish]; BRN 0088554; 10-(2-(Dimethylamino)propyl)phenothiazine; Lilly 01516; PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3); CHEBI:8461; Promethazinum [INN-Latin]; Pyrethiazine; Pyrethia; Proazaimine; Pilpophen; N-Dimethylamino-2-methylethyl thiodiphenylamine; Fargan; C07404; RP 3277; BPBio1_000744; (Dimethylamino-2-propyl-10-phenothiazine hydrochloride; Promazinamide; Spectrum2_000840; A-91033; Protazine; Prometh; (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; SPBio_000799; Prometazine; Romergan; Dimethylamino-isopropyl-phenthiazin; NCGC00015817-10; Spectrum5_000977; Pelpica; Promezathine; 10-[2-(Dimethylamino)propyl]phenothiazine; promethazine; NSC30321; 38878-40-9; Zipan-25; Remsed; PWWVAXIEGOYWEE-UHFFFAOYSA-; Diprazine; Prestwick0_000888; Pro-50; Lergigan; Pipolphene; Avomine; Lopac0_000899; DivK1c_000005; CID4927; MolPort-001-783-684; Spectrum4_001149; Isopromethazine; Prometazin; Diphergan; Promergan; Pilothia; LS-264; Dimapp; 3277 RP; Antiallersin; Fenetazina; IDI1_000005; Promethazine (JAN/INN); L000495; SPBio_002895; Lercigan; Aprobit; InChI=1/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+); Promethacon; Prorex; N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride; Fenetazine; SKF 1498; Prothazine; Rumergan; Promesan; Spectrum_000868; Provigan; WLN: T C666 BN ISJ B1Y1&N1&1; 10-(2-Dimethylaminopropyl)phenothiazine; Prestwick3_000888; Valergine; BSPBio_000676; N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- (9CI); Fenazil; 10H-Phenothiazine-10-ethanamine, N,N,.alpha.-trimethyl-; Promethazinum; UNII-FF28EJQ494; Phenothiazine, 10-(2-dimethylaminopropyl)-; Promethazine [INN:BAN]; Tanidil; Iergigan; NCGC00089735-02; BSPBio_002777; Proazamine; NINDS_000005; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-; EINECS 200-489-2; 4-27-00-01253 (Beilstein Handbook Reference); Phenoject-50; N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine    
Trade NamePhenergan; Promethegan; Romergan; Fargan; Farganesse; Prothiazine; Avomine; Atosil; Receptozine; Lergigan    
CompanyWyeth Pharmaceuticals    
IndicationAllergic disorders, itching, nausea and vomitingApproved    [1]
Structure

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Therapeutic ClassAnti-Allergic Agents    
CAS NumberCAS 60-87-7
FormularC17H20N2S    
PubChem Compound IDCID 4927.    
PubChem Substance IDSID 9608.    
ChEBI8461;    
SuperDrug ATC IDD04AA10;    
SuperDrug CAS ID000060877;    
TargetHistamine H1 receptorAntagonist[2][3]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089013 To Reference
Ref 2Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29. To Reference
Ref 3Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. To Reference



 

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