Therapeutic Targets Database
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TTD Drug ID: DAP000494

Drug Information
NameDuloxetine    
SynonymsPDSP2_001369; PDSP2_000953; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; CHEMBL1175; (S)-Duloxetine; 116539-59-4; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine; MLS000758267; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; LS-172322; SAM001247059; Cymbalta; CHEBI:36795; CPD000449282; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; AC-15704; C18H19NOS; PDSP1_001385; Yentreve; NCGC00164559-01; MolPort-003-847-038; AC1L1U0Q; CID60835; HSDB 7368; 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (S)-; Duloxetine (INN); Yentreve (TN); AC1Q57H7; Duloxetine [INN:BAN]; UNII-O5TNM5N07U; duloxetine; LY 248686; 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)-; D07880; DB00476; PDSP1_000969; HMS2051I05; MLS001423946; SMR000449282; duloxetine, (+)-isomer    
Trade NameCymbalta    
CompanyEli Lilly and Company    
IndicationDepressionApproved    [1]
Structure

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Therapeutic ClassAntidepressive Agents    
CAS NumberCAS 136434-34-9
FormularC18H19NOS    
PubChem Compound IDCID 60835.    
PubChem Substance IDSID 704934.    
ChEBI31526;    
TargetNoradrenergic re-uptakeInhibitor[2][3]
Noradrenergic re-uptakeMultitarget[2][3]
Serotonin reuptakeInhibitor[2][3]
Serotonin reuptakeMultitarget[2][3]
Ref 1Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39. To Reference
Ref 2Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. Epub 2006 Nov 28. To Reference
Ref 3Duloxetine for the treatment of generalized anxiety disorder: a review. Neuropsychiatr Dis Treat. 2009;5:23-31. Epub 2009 Apr 8. To Reference



 

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