Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DAP000614

Drug Information
NameSildenafil    
SynonymsKBio2_002035; KBioGR_001052; C22H30N6O4S; 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one; 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Ambap139755-83-2; 171599-83-0 (citrate); I06-0023; VIA; 2h42; SMR000752512; Spectrum2_001648; Piperazine, 1-((3-(4,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methyl-; Aphrodil (TN); 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (Sildenafil or Viagra); Sildenafil (INN); HMS2089M12; KBio1_001838; UK-92,480-10; LS-111655; BAS 04213629; Sildenafil [INN:BAN]; DB00203; D08514; 1udt; AC-938; BIDD:GT0352; HMS1922B19; sildenafil; HMS2093O17; NCGC00095099-01; 5-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one; SpecPlus_000798; KBioSS_002035; Aphrodil; Spectrum5_001508; 5-{2-(ethyloxy)-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; NCGC00095099-02; MolPort-001-995-394; UK-92480; 139755-83-2; 1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine; HMS1684K08; MLS001240224; CHEBI:9139; KBio2_004603; HSDB 7305; 1xos; DivK1c_006894; MolPort-002-885-861; Spectrum_001555; UNII-3M7OB98Y7H; MLS001304737; KBio2_007171; Spectrum3_001892; BSPBio_003424; SPECTRUM1504099; Jsp002373; 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate; AC1L1JUI; CID5212; SPBio_001775; BRD-K79759585-001-02-1; NCGC00159496-02; Spectrum4_000586; KBio3_002927; 5-[2-Ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one(Sildenafil); CHEMBL192; C07259    
Trade NameViagra; Revatio    
CompanyPfizer Pharmaceuticals    
IndicationErectile dysfunctionApproved    [1]
Structure

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Click to save drug structure in 2D MOL format
   
Therapeutic ClassAnti-Impotence Agents    
CAS NumberCAS 139755-83-2
FormularC22H30N6O4S    
PubChem Compound IDCID 5212.    
PubChem Substance IDSID 9468.    
SuperDrug ATC IDG04BE03;    
SuperDrug CAS ID139755832;    
TargetCGMP-specific 3',5'-cyclic phosphodiesteraseInhibitor[2][3][4][5]
Ref 1Pharmacologic therapeutics for cardiac reperfusion injury. Expert Opin Emerg Drugs. 2007 Sep;12(3):367-88. To Reference
Ref 2cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. J Pharmacol Exp Ther. 2009 Jun 22. [Epub ahead of print] To Reference
Ref 3Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review. Urology. 2002 Sep;60(2 Suppl 2):49-57. To Reference
Ref 4Nat Rev Drug Discov. 2003 Jan;2(1):38-51.Knockouts model the 100 best-selling drugs--will they model the next 100? To Reference
Ref 5Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res. 2002 Dec;14(6):466-71. To Reference



 

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