Therapeutic Targets Database
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TTD Drug ID: DAP000648

Drug Information
NameTopotecan    
Synonyms(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NChemBio.2007.10-comp24; BSPBio_002348; SKF-S 104864; topotecan; C23H23N3O5; HSCI1_000228; SKF 104864; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; Topotecane [INN-French]; MLS000759456; Topotecanum [INN-Latin]; Topotecan lactone; Hycamtin; NCIStruc2_001796; Topotecanum; Topotecan [INN:BAN]; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; TOPOTECAN, HYCAMTIN; CHEBI:107501; C11158; Topotecane; D08618; NCI60_004771; Topotecan (BAN); NCGC00178695-01; AC1L1TQZ; SMR000466344; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; SK&F-104864-A; (S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; AC1Q6APZ; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, (S)-; CCRIS 8163; Topotecan Monohydrochloride, (S)-Isomer; AC-11592; CHEBI:46035; CHEMBL84; 123948-87-8; SKF-104864-A; CID60700; SMP2_000312; LS-127395; 9-Dimethylaminomethyl-10-hydroxycamptothecin; Hycamtamine; Hycamptamine; UNII-7M7YKX2N15; Hycamtin (TN); NCIStruc1_001659; HMS2090B20; DB01030; Hycamptin; (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC609699; (S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; SMP2_000327    
Trade NameHycamtin    
CompanyGlaxoSmithKline    
IndicationOvarian cancerApproved    [1]
Structure

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Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 119413-54-6
FormularC23H23N3O5    
PubChem Compound IDCID 60700.    
PubChem Substance IDSID 13340.    
SuperDrug ATC IDL01XX17;    
SuperDrug CAS ID123948878;    
TargetDNA topoisomerase IInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2New advances in lung cancer chemotherapy: topotecan and the role of topoisomerase I inhibitors. Oncology. 2001;61 Suppl 1:14-24. To Reference
Ref 3Camptothecins in clinical development. Expert Opin Investig Drugs. 2004 Mar;13(3):269-84. To Reference



 

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