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TTD Drug ID: DAP000650

Drug Information
NameValrubicin    
SynonymsCHEMBL20225; 136816-53-0; [2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate; Valstar Preservative Free; N-Trifluoroacetyladriamycin 14-valerate; NSC-246131; HSDB 7288; Pentanoic acid, 2-((2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetylamino)-, alpha-L-lysohexopyranoxyl)oxy)-2-naphthacenyl)-2-oxoethyl ester; I06-1096; Valrubicin (USP/INN); NSC246131; Pentanoic acid, 2-[1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-.alpha.-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester, (2S-cis)-; 56124-62-0; Valstar (TN); UNII-2C6NUM6878; AC1L26EA; C34H36F3NO13; LS-15286; Valrubicin [USAN]; Trifluoroacetyladriamycin-14-valerate; CID41744; (2S-cis)-Pentanoic acid, 2-(1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphth acenyl)-2-oxoethyl ester; (2S-cis)-2-(1,2,3,4,6,11-Hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-lyxo-hexopyranosyl)oxy)-2-naphthacenyl)-2-oxoethyl pentanoate; AD 32; (8S,10S)-8-Glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-alpha-L-lyxo-hexopyranosyl)oxy)-5,12-naphthacenedione 8(sup 2)-valerate; NCI60_001970; Antibiotic AD 32; Valstar; N-Trifluoroacetyladriamycin-14-valerate; Valrubicin; Adriamycin, trifluoroacetyl-, 14-valerate; N-Trifluoroacetyldoxorubicin 14-valerate; DB00385; D02697; NSC 246131    
Trade NameValstar    
IndicationBladder cancerApproved    [1]
Structure

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Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 56124-62-0
FormularC34H36F3NO13    
PubChem Compound IDCID 41744.    
PubChem Substance IDSID 136463.    
SuperDrug ATC IDL01DB09;    
SuperDrug CAS ID056124620;    
TargetDNA topoisomerase IIInhibitor[2]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II. NCI Monogr. 1987;(4):111-5. To Reference



 

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