Therapeutic Targets Database
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TTD Drug ID: DAP000659

Drug Information
NameCerulenin    
SynonymsNCGC00163492-02; (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide; Bio2_000478; (2R,3S)-3-nona-4,7-dienoyloxirane-2-carboxamide; C12058; KBioSS_000616; LS-63388; KBio3_001091; 3-nona-4,7-dienoyloxirane-2-carboxamide; cerulenin; Helicocerin; AC1L1FI4; AC1L6R79; 2,3-Epoxy-4-oxo-7,10-dodecadienoylamide; C2389_SIGMA; NCI60_000363; 7,10-DODECADIENAMIDE, 2,3-EPOXY-4-OXO-; KBio2_000616; (2R-(2alpha,3alpha(4E,7E)))-3-(1-Oxonona-4,7-dienyl)oxirane-2-carboxamide; KBio2_003184; 17397-89-6; KBio2_005752; NSC116069; CID28517; (2S)(3R)-2,3-Epoxy-4-oxo-7,10-dodecadienoylamide; NCGC00163492-01; AC1NQZF4; HMS1990P17; CID5352018; Bio2_000958; AC1Q5H5H; (2S,3R)-2,3-epoxy-4-oxy-7,10-dodecadienoylamide; Cerulenin, Cephalosporium caerulens; (2R,3S)-2,3-Epoxy-4-oxo-7E,10E-dodecadienamide; CID5282054; SMP1_000098; 2,3-Epoxy-4-oxo-7,10-dodecadienamide; BRD-K52075040-001-02-2; (2r,3s)-3-(nona-4,7-dienoyl)oxirane-2-carboxamide; QTL1_000017; 3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide; Oxiranecarboxamide, 3-(1-oxo-4,7-nonadienyl)-, (2R-(2alpha,3alpha(4E,7E)))-; Oxiranecarboxamide, 3-[(4E,7E)-1-Oxo-4,7-nonadienyl]-, (2R,3S)-; DB01034; AC1NS1LT; NSC 116069; CHEMBL45627; Ambotz17397-89-6; CID272023; CHEBI:171741; KBioGR_000616; IDI1_002233; Oxiranecarboxamide, 3-(1-oxo-4,7-nonadienyl)-, (2R-(2-alpha,3-alpha(4E,7E)))-; (2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide; MolPort-003-928-099; KBio3_001092; CPD-6901; (2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide; HMS1362P17; EINECS 241-424-8; BSPBio_001276; (2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide; HMS1792P17; 3-(1-Oxo-4,7-nonadienyl)oxiranecarboxamide; Oxiranecarboxamide, 3-(1-oxo-4,7-nonadienyl)-, (2R-(2-alpha,3-alpha(4E,7E)))- (9CI)    
IndicationDramatic weight lossApproved    [1]
Structure

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Therapeutic ClassAnti-Infective Agents    
CAS NumberCAS 17397-89-6
FormularC12H17NO3    
PubChem Compound IDCID 5352018.    
PubChem Substance IDSID 8139660.    
TargetFatty acid synthaseInhibitor[2][3][4]
Ref 1Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. To Reference
Ref 2Inhibition of Fatty Acid Biosynthesis Prevents Adipocyte Lipotoxicity on Human Osteoblasts In Vitro. J Cell Mol Med. 2009 Mar 27. [Epub ahead of print] To Reference
Ref 3Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor--cerulenin. Zhonghua Xue Ye Xue Za Zhi. 2000 May;21(5):244-6. To Reference
Ref 4The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev. 1976 Sep;40(3):681-97. To Reference



 

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