TTD Drug ID: DAP000759

Drug Information
Name	Raltitrexed
Synonyms	Tomudex, TDX, ZD 1694, Raltitrexed; D 1694; N-(5-(((3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thenoyl)-L-glutamic acid; ZD-1694; AstraZeneca brand of raltitrexed; L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)-; 1i00; CPD000469217; SAM001246796; SA-Detection Disk Kit; Bio-0142; 2kce; C21H22N4O6S; Raltitrexed; CHEBI:474007; Raltitrexed (JAN/USAN/INN); 2tsr; CHEBI:41742; CID104758; NSC639186; ZD1694; D16; ZD 1694; SMR000469217; S1192_Selleck; Arkomedika brand of raltitrexed; MLS001424225; (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid; HMS2052I03; ICI D1694; D-1694; Tomudex; KS-5069; D1694; D01064; N-(5-(N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid; DB00293; Tomudex (TN); CHEMBL225071; LS-71840; C068874; AC-19671; ZD-16; 112887-68-0; ZN-D1694; ICI-D1694; NSC-639186; Zeneca brand of raltitrexed; (S)-2-[(1-{5-[Methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid; ICI-D-1694; AC1L2XFZ; NCI60_013008; C11372
Trade Name	Tomudex
Company	AstraZeneca
Indication	Colon and rectum cancers			Approved    [1]
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
Therapeutic Class	Antineoplastic Agents
CAS Number	CAS 112887-68-0
Formular	C21H22N4O6S
PubChem Compound ID	CID 104758.
PubChem Substance ID	SID 13546.
SuperDrug ATC ID	L01BA03;
SuperDrug CAS ID	112887680;
Target	Thymidylate synthase			Inhibitor	[2][3]
Ref 1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2	DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15;76(8):987-96. Epub 2008 Aug 19. To Reference
Ref 3	Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Semin Oncol. 1999 Apr;26(2 Suppl 6):48-54. To Reference

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