Therapeutic Targets Database
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TTD Drug ID: DAP001010

Drug Information
NameErlotinib    
Synonyms[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; Erlotinib, OS-774; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-; CP-358,774; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; CID176870; Erlotinib(Tarceva); N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; CHEMBL553; R 1415; Kinome_3317; AQ4; CP 358,774; NCGC00164574-01; OSI 744; ZINC01546066; HMS2089F05; AB1004620; Erlotinib; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; SR-05000001460; Tarceva; EN002711; BCB03_000783; AKOS000282911; CP-358774; K00241; NSC 718781; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; LS-184395; UNII-J4T82NDH7E; AC1L42EI; DB00530; STK623143; SR-05000001460-2; C400278; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; n-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; Erlotinin; Erlotinib Base; 183321-74-6; CHEBI:114785; I01-1241; AC-399; FT-0083688; nchembio866-comp3; MolPort-003-847-084    
Trade NameTarceva    
CompanyOSI Pharma.    
IndicationColon, glioma, breast, RCC ovarian, head & neck cancerPhase II    [1]
Non-small cell lung cancerLaunched    [1]
Pancreatic cancerPhase III    [1]
Structure

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Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 183321-74-6
FormularC22H23N3O4    
PubChem Compound IDCID 176870.    
PubChem Substance IDSID 754070.    
TargetEpidermal growth factor receptorInhibitor[2]
Epidermal growth factor receptorInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Quantitative Prediction of Fold Resistance for Inhibitors of EGFR. Biochemistry. 2009 Jul 23. [Epub ahead of print] To Reference
Ref 3Roche. Product Development Pipeline. July 29 2009. To Reference



 

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