Therapeutic Targets Database
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TTD Drug ID: DAP001082

Drug Information
NameVorinostat    
SynonymsZINC01543873; NSC701852; UNII-58IFB293JI; N-Hyrdroxy-N'-phenyloctanediamide; Vorinostat; N-hydroxy-N'-phenyloctanediamide; Merck brand of Vorinostat; WIN64652; Vorinostat [USAN]; N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide; NSC-701852; NHNPODA; Zolinza; m344; SAHA, Suberoylanilide hydroxamic acid; N-Hydroxy-N'-phenyl octanediamide; SMR000486344; Zolinza (TN); CID5311; CHEMBL98; Zolinza, MK-0683, SAHA; S1047_Selleck; suberoylanilide hydroxamic acid; nchembio815-comp18; OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE; D06320; SKI390; LS-187780; AC-1923; N'-hydroxy-N-phenyloctanediamide; EC-000.2057; CCRIS 8456; nchembio.275-comp2; 1zz1; MLS001065855; MK0683; SHH; N1-hydroxy-N8-phenyloctanediamide; SAHA; LS-186997; NCGC00168085-02; MK-0683; SAHA cpd; AC1L1K2K; Vorinostat MSD; C111237; LS-186548; Suberanilohydroxamic acid; Octanediamide, N-hydroxy-N'-phenyl-; Vorinostat (JAN/USAN); FT-0082592; CHEBI:45716; SW-064652; DB02546; nchembio.313-comp1; MolPort-003-850-293; BRD-K81418486-001-10-3; 149647-78-9    
Trade NameZolinza    
CompanyMerck & Co., Inc.    
IndicationCutaneous T-cell lymphomaApproved    [1]
Structure

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Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 149647-78-9
FormularC14H20N2O3    
PubChem Compound IDCID 5311.    
PubChem Substance IDSID 730694.    
TargetHistone deacetylase 1Inhibitor[2][3][4]
Ref 1Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. To Reference
Ref 2Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32. To Reference
Ref 3Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties. J Med Chem. 2009 Jun 11;52(11):3453-6. To Reference
Ref 4Nat Rev Drug Discov. 2006 Sep;5(9):769-84.Anticancer activities of histone deacetylase inhibitors. To Reference



 

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