Therapeutic Targets Database
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TTD Drug ID: DAP001101

Drug Information
NamePosaconazole    
SynonymsSpriafil; CID11520437; 171228-49-2; Posaconazole in combination with MGCD290; UNII-6TK1G07BHZ; HSDB 7421; DB01263; Posaconazole; Posaconazole SP; CHEMBL371939; CHEMBL1397; AC1L3W34; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one; CID147912; CID468595; CHEBI:434337; Posaconazole [USAN:INN:BAN]; Noxafil (TN); AC1LAHLQ; Noxafil, Posaconazole; 3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl)methoxy)phenyl)-1-piperazinyl)phenyl)-2-(1-ethyl-2-hydroxypropyl)-2,4-dihydro-, (3R-(3alpha(1S*,2S*),5alpha))-; CID11542142; 4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one; D02555; Sch 56592; LS-187630; Noxafil; LS-186118; AC-1350; MolPort-006-666-426; X2N; CHEMBL371938; SCH-56592; D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-((4-(4-(4-(1-((1S,2S)-1-etyl-2-hydroxypropyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl)phenyl)-1-piperazinyl)phenoxy)methyl)-1-(1H-1,2,4-triazol-1-yl)-; S1257_Selleck; 1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one; AKOS005145917; LS-186988; Posaconazole (USAN/INN); 177571-33-4; SCH56592; CID10532764; 4-(p-(4-(p-(((3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furyl)methoxy)phenyl)-1-piperazinyl)phenyl)-1-((1S,2S)-1-ethyl-2-hydroxypropyl)-delta(sup 2)-1,2,4-triazolin-5-one    
Trade NameNoxafil    
CompanySchering-Plough    
IndicationFungal infectionsApproved    [1]
Structure

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Therapeutic ClassAntifungal Agents    
CAS NumberCAS 171228-49-2
FormularC37H42F2N8O4    
PubChem Compound IDCID 21309251.    
PubChem Substance IDSID 17396726.    
TargetLanosterol 14-alpha demethylaseInhibitor[2]
Ref 1FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022003 To Reference
Ref 2A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6. To Reference



 

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