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TTD Drug ID: DAP001213

Drug Information
NameEpoprostenol    
SynonymsPGX; AC1NR00P; AC1L3FZB; Epoprostenolum [INN-Latin]; BRD-K64054020-001-02-7; KBioSS_000216; 61849-14-7; prostaglandin I2; 5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; TRY 200; CHEBI:15552; (5E)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3R)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; C01312; epoprostenol; (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoic acid; Bio2_000216; Epoprostanol; Epoprostenolum; 6,9-alpha-Epoxy-11-alpha,15(S)-dihydroxyprosta-5(Z),13(E)-dien-1-oic acid; U 53,217; KBioGR_000216; CHEMBL1139; KBio2_005352; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-; (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate; AR-1I7150; AC1NQX0K; (5Z)-5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; Bio2_000696; KBio2_002784; Try-200; PDSP2_001704; NCGC00161285-02; NCGC00161285-03; KBio2_000216; (Z)-(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S)-3-hydroxy-1-octenyl)-2H-cyclopenta(b)furan-delta(sup 2,delta)-valeric acid; CID5282411; Prostacyclins; Prostaglandin I(2); CID6450541; DB01240; Epoprostenol (TN); CID11969614; CID114805; PG-I2; 5-[5-hydroxy-4-(3-hydroxyoct-1-enyl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; KBio3_000432; BRN 1690090; U-53217; AC1L18LX; prostacyclin; 5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; 35121-78-9; 136626-78-3; Prostacycline; CHEMBL307845; NCGC00161285-01; CID159; Vasocyclin; LMFA03010087; BSPBio_001496; CID9864371; KBio3_000431; D00106; CID6434194; LS-125828; CID5280427; BIDD:GT0514; AC1O51WG; Epoprostenol [USAN:INN]; IDI1_033966; Prostaglandin I; 63859-31-4; PGI(sub 2); KB-IV-24; PDSP1_001721; Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9alpha,11alpha,13E,15S)-; Flolan; SMP2_000227; HMS1989K18; UNII-DCR9Z582X0; Prostaglandins X; Epoprostenol (USAN/INN); AC1O5HI7; HMS1791K18; Prostaglandin X; 63748-50-5; (5Z,9alpha,11alpha,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid; (5Z,9alpha,11alpha,13E,15S)-11,15-dihydroxy-6,9-epoxyprosta-5,13-dien-1-oic acid; (5Z)-5-[(4R,5R)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-2-ylidene]pentanoic acid; PGI2; CID9975312; Prostacyclin I2    
IndicationPulmonary hypertensionApproved    [1]
Structure

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Therapeutic ClassAntihypertensive Agents    
CAS NumberCAS 35121-78-9
FormularC20H32O5    
PubChem Compound IDCID 159.    
PubChem Substance IDSID 5173371.    
ChEBI15552;    
SuperDrug ATC IDB01AC09;    
SuperDrug CAS ID035121789;    
TargetProstacyclin receptorAgonist[2][3][4]
Ref 1Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. To Reference
Ref 2Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation. J Mol Cell Cardiol. 2009 May;46(5):682-94. Epub 2009 Jan 23. To Reference
Ref 3Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem. 2002 Nov 29;277(48):46035-42. Epub 2002 Sep 23. To Reference
Ref 4Expression of human hexosaminidase-A phenotype depends on genes assigned to chromosomes 5 and 15. Birth Defects Orig Artic Ser. 1976;12(7):192-6. To Reference



 

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