Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DAP001244

Drug Information
NameLeucovorin/5-fluorouracil    
IndicationColon CancerApproved    [1]
Therapeutic ClassVitamins    
CAS NumberCAS 1492-18-8
FormularC20H23N7O7    
SuperDrug ATC IDV03AF03;    
SuperDrug CAS ID001492188;    
TargetThymidylate synthaseInhibitor[2][3]
Ref 1Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. To Reference
Ref 2Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance. Mol Cancer Ther. 2009 Apr 21. [Epub ahead of print] To Reference
Ref 3Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward? Cancer Biol Ther. 2008 Jul;7(7):986-94. Epub 2008 Apr 21. To Reference



 

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National University of Singapore, Singapore


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