Therapeutic Targets Database
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TTD Drug ID: DAP001262

Drug Information
NameDiltiazem    
SynonymsCardil; d-cis-Diltiazem; Tocris-0685; STOCK1N-03672; Cardizen LA; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-; NCGC00024309-06; BRN 3573079; DB00343; HMS2089H09; UNII-EE92BBP03H; Viazem; Tiazac Tildiem; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; Dilren; Prestwick2_000134; Cardizem (Hydrochloride); Apo-Diltiaz; Dilta-Hexal; 33286-22-5; Citizem; [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate; Diltzac; NCGC00024309-07; 42399-41-7; CID39186; BPBio1_000230; Lopac0_000327; Diltiazemum; AC1Q6LHX; BIDD:GT0548; Diltia; Prestwick3_000134; Anoheal; BSPBio_001311; NCGC00024309-08; NCGC00024309-02; diltiazem; (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate; Diltiazem [INN:BAN]; Diltiazem (INN); 144604-00-2; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-; Incoril AP; Dilticard; Bio1_000860; Adizem; NCGC00024309-09; (2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one; Bio1_000371; Surazem (TN); C22H26N2O4S; LS-40510; Tiazac XC; HMS1791B13; BSPBio_000208; AC1L2181; Aldizem; BRD-K24023109-001-02-5; Prestwick0_000134; RG 83606 (Hydrochloride); (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester; NCGC00024309-10; (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate; Bio1_001349; CHEBI:101278; Dilzen; Diltiazemum [INN-Latin]; CHEMBL23; SPBio_002147; Prestwick1_000134; EINECS 255-796-4; AC-936; MK-793 (Malate); NCGC00024309-04; Dilacor; BRD-K24023109-003-03-9; Dilacor-XR; FT-0081415; Dilt-cd; Endrydil; Acalix; Cardizem; Dilcontin; C06958; HSDB 6528; nchembio.368-comp1; Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; MolPort-002-509-369; D07845; Nu-Diltiaz; HMS1989B13; NCGC00024309-05    
Trade NameProgor; Herben; Altiazem; Cardizem; Cartia XT; Tiazac; Tiazac XC; Tiamate; Tildiem; Adizem; Viazem; Dilatam; Dilzem; Angiozem; Dilatem; Dilcardia; Diltelan; Diltime; Dyalec; Filazem; Tildiem; Vasmulax; Zandil; Zemtrial; Angizem CD; Angizem; Dilcontin SR    
IndicationHypertensionApproved    [1]
Structure

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Therapeutic ClassAntihypertensive Agents    
CAS NumberCAS 42399-41-7
FormularC22H26N2O4S    
PubChem Compound IDCID 39186.    
PubChem Substance IDSID 9173.    
SuperDrug ATC IDC08DB01;    
SuperDrug CAS ID042399417;    
TargetVoltage-dependent calcium channelBlocker[2]
Ref 1Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol. 2008 Feb;6(2):e26. To Reference
Ref 2Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24. Epub 2009 Jul 1. To Reference



 

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