Therapeutic Targets Database
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TTD Drug ID: DAP001378

Drug Information
NameDimethindene maleate    
SynonymsDimetindene hydrogen maleate; Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-, maleate (1:1); Dimethinden maleate; Dimethindene Malenate; 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (Z)-2-butenedioate (1:1); Forhistal maleate (TN); Dimetindene maleate; LS-131453; 5636-83-9 (Parent); MLS002704010; C20H24N2.C4H4O4; 1H-Indene-2-ethanamine, N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (Z)-2-butenedioate (1:1); Pyridine, 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]-, maleate (1:1); Forhistal maleate; Forthistal maleate; NSC 107677; Z 820; SMR001570719; AC1NR00Y; Dimetindene maleate (JAN); EINECS 222-789-2; Dimethindene maleate; D01343; Dimethindene maleate (USAN); I14-13956; Dimethindene maleate [USAN]; SU-6518; Dimethpyrindene maleate; UNII-6LL60J9E0O; (Z)-but-2-enedioic acid; N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine; Fenistil; SU 6518; 2-(1-(2-(2-(Dimethylamino)ethyl)inden-3-yl)ethyl)pyridine maleate (1:1); CID5282414; NSC107677; 2-[1-[2-[2-(Dimethylamino)ethyl]inden-3-yl]ethyl]pyridine maleate (1:1); Triten; Fenistil-retard; 2-(1-(2-(2-(Dimethylamino)ethyl)inden-3-yl)ethyl)pyridine maleate; 3614-69-5    
IndicationRespiratory allergiesApproved    [1]
Structure

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Therapeutic ClassAnti-Allergic Agents    
CAS NumberCAS 3614-69-5
FormularC24H28N2O4    
PubChem Compound IDCID 5282414.    
PubChem Substance IDSID 407402.    
TargetHistamine H1 receptorAntagonist[2][1][3][4]
Ref 1Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9. To Reference
Ref 2Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93. To Reference
Ref 3Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Rhinology. 2003 Sep;41(3):159-66. To Reference
Ref 4Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. To Reference



 

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