Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DAP001427

Drug Information
SynonymsSarpogrelate [INN]; 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid; Sarpogrelate (INN); D08508; 125926-17-2; UNII-19P708E787; butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester; CID5160; AR-1I1045; AC1L1JQL; AC1Q5VS0; L000858; CHEMBL52939; STK631325; CHEBI:180532; 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid; LS-187118; NCGC00167489-01; 135309-80-7    
IndicationDiabetes mellitusApproved    [1]

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Therapeutic ClassHypoglycemic Agents    
CAS NumberCAS 125926-17-2
PubChem Compound IDCID 5160.    
PubChem Substance IDSID 3862730.    
Target5-hydroxytryptamine 2A receptorAntagonist[2][3][3][4]
Ref 1A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs. Yakushigaku Zasshi. 2003;38(1):93-105. To Reference
Ref 2Beneficial effects of sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, supplemented with pioglitazone on diabetic model mice. Endocr Res. 2009;34(1-2):18-30. To Reference
Ref 3Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur J Pharmacol. 2009 Jul 1;614(1-3):122-7. Epub 2009 Mar 24. To Reference
Ref 4Therapeutic effect of sarpogrelate, a new 5-hydroxytryptamine receptor 2A antagonist, on diabetic nephropathy and neuropathy. Nephron. 1997;76(2):227-9. To Reference


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