Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DCL000006

Drug Information
NameSNS-314    
SynonymsSN-314; SNS-314; DB07361; CHEMBL518051; Kinome_3712; AK2    
CompanySunesis Pharma.    
IndicationSolid TumorsPhase I completed    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
   
Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 1057249-41-8
PubChem Compound IDCID 24995524.    
PubChem Substance IDSID 56464763.    
ClinicalTrials.govNCT00519662;    
TargetAurora-AInhibitor[1][2][3][4][1]
Aurora-AMultitarget[1][2][3][4][1]
Aurora-BInhibitor[1][2][3][4][1]
Aurora-BMultitarget[1][2][3][4][1]
Aurora-CInhibitor[1][2][3][4][1]
Aurora-CMultitarget[1][2][3][4][1]
Ref 1SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2009 Aug 1. [Epub ahead of print] To Reference
Ref 2The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol Cancer Ther. 2009 Apr;8(4):930-9. To Reference
Ref 3Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57. To Reference
Ref 4Water-soluble prodrugs of an Aurora kinase inhibitor. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1409-12. Epub 2009 Jan 19. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543