Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000169

Drug Information
SynonymsCHEMBL259084; CID 11712649; MLN8054; ZZL; Kinome_1204; S1100_Selleck; CID11712649; EC-000.2342; MLN-8054    
CompanyMillennium, Takeda    
IndicationAdvanced malignanciesTerminated in Phase I    
Solid tumoursTerminated in Phase I    

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Therapeutic ClassAntineoplastic Agents    
CAS NumberCAS 869363-13-3
PubChem Compound IDCID 11712649.    
PubChem Substance IDSID 16817521.    
TargetAurora A kinase Inhibitor[1][2][3]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 2Takeda. Product Development Pipeline. July 31 2009. To Reference
Ref 3MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol. 2007 Jun;27(12):4513-25. Epub 2007 Apr 16. To Reference


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