Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DCL000259

Drug Information
SynonymsVX-680; MK 0457; Cyclopropanecarboxylic acid N-(4-((4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl)sulfanyl)phenyl)amide; Cyclopropanecarboxylic Acid {4-[4-(4-Methyl-Piperazin-1-Yl)-6-(5-Methyl-2h-Pyrazol-3-Ylamino)-Pyrimidin-2-Ylsulfanyl]-Phenyl}-Amide; VX6; Tozasertib (USAN); AC1NUV5F; VX-68; Cyclopropanecarboxamide, N-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)-; MLS001065920; CID5494449; CHEMBL572878; L-001281814; Kinome_3803; S1048_Selleck; Tozasertib; ST51054127; Cyclopropane carboxylic acid{4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulphanyl]-phenyl}-amide; 2f4j; MK-0457, Tozasertib, VX680, VX-680; NSC745967; EC-000.2365; MK-045; SMR000486395; D08279; VX 680; 639089-54-6; MK-0457; I14-1964; N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide; N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide    
IndicationChronic Myelogenous Leukemia; Leukemia; Lymphoblastic, Acute, Philadelphia-PositiveTerminated in Phase I    
LeukemiaTerminated in Phase II    

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Therapeutic ClassAntineoplastic Agents    
PubChem Compound IDCID 5494449.    
PubChem Substance IDSID 3821044.    
Proto-oncogene tyrosine-protein kinase LCKInhibitor[1][2]
Proto-oncogene tyrosine-protein kinase LCKMultitarget[1][2]
Ref 1A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. To Reference
Ref 2Essential roles of mTOR/Akt pathway in Aurora-A cell transformation. Int J Biol Sci. 2009 Jun 19;5(5):444-50. To Reference


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