Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DCL000680

Drug Information
NameAdatanserin    
SynonymsWY 50324; N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide; Adatanserin [INN]; Tricyclo(3.3.1.1(3,7))decane-1-carboxamide, N-(2-(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)-; CID130918; UNII-W5U6WQM26H; L001372; AC1L2Y9D; Adatanserin; 144966-96-1 (Monohydrochloride); 127266-56-2    
CompanyWyeth    
IndicationSevere Mood DisordersDiscontinued in Phase II    [1]
Structure

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Click to save drug structure in 2D MOL format
   
CAS NumberCAS 127266-56-2
FormularC21H31N5O    
PubChem Compound IDCID 130918.    
PubChem Substance IDSID 707386.    
Target5-hydroxytryptamine receptor 1A Multitarget[1][2]
5-hydroxytryptamine receptor 1A Agonist[1][2]
5-hydroxytryptamine receptor 2A Antagonist[1][2]
5-hydroxytryptamine receptor 2A Multitarget[1][2]
Ref 1Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. To Reference
Ref 2J Med Chem. 1999 Dec 16;42(25):5077-94.Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. To Reference



 

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