TTD Drug ID: DCL000680

Drug Information
Name	Adatanserin
Synonyms	WY 50324; N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide; Adatanserin [INN]; Tricyclo(3.3.1.1(3,7))decane-1-carboxamide, N-(2-(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)-; CID130918; UNII-W5U6WQM26H; L001372; AC1L2Y9D; Adatanserin; 144966-96-1 (Monohydrochloride); 127266-56-2
Company	Wyeth
Indication	Severe Mood Disorders			Discontinued in Phase II    [1]
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
CAS Number	CAS 127266-56-2
Formular	C21H31N5O
PubChem Compound ID	CID 130918.
PubChem Substance ID	SID 707386.
Target	5-hydroxytryptamine receptor 1A			Multitarget	[1][2]
	5-hydroxytryptamine receptor 1A			Agonist	[1][2]
	5-hydroxytryptamine receptor 2A			Antagonist	[1][2]
	5-hydroxytryptamine receptor 2A			Multitarget	[1][2]
Ref 1	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2. To Reference
Ref 2	J Med Chem. 1999 Dec 16;42(25):5077-94.Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. To Reference

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