Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DCL001078

Drug Information
NamePHA-739358    
Synonyms5-Amido-pyrrolopyrazole 9d; CID11442891; UNII-M3X659D0FY; S1107_Selleck; Danusertib, PHA-739358; CID 11994441; CHEMBL402548; PHA-739358; I06-2258; PHA 739358; Danusertib; (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-c)pyrazol-3-yl)-; 2j50; EC-000.2352; EN003071; 827318-97-8    
CompanyPfizer/Nerviano    
IndicationCML that relapsed after imatinib or BCR¨CABL-targeted therapy; Metastatic Hormone Refractory Prostate Cancer (MHRPC)Phase II    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
   
PubChem Compound IDCID 11442891.    
PubChem Substance IDSID 16541138.    
ClinicalTrials.govNCT00766324;    
TargetAurora AInhibitor[1]
Aurora AMultitarget[1]
Aurora BInhibitor[1]
Aurora BMultitarget[1]
Ref 1Nat Rev Drug Discov. 2009 Jul;8(7):547-66.Cell cycle kinases as therapeutic targets for cancer. To Reference



 

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