Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DNC000909

Drug Information
NameLY53857    
Structure

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CAS NumberCAS 60634-51-7
PubChem Compound IDCID 6437377.    
PubChem Substance IDSID 685308.    
Target5-hydroxytryptamine 2A receptorAntagonist[1][2][3][4]
5-hydroxytryptamine 2B receptorAntagonist[4]
5-hydroxytryptamine 2C receptorAntagonist[1][2][3][4]
Ref 1The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. Epub 2007 Feb 8. To Reference
Ref 2Some studies on the 5-hydroxytryptamine receptors in the isolated rat uterus. Afr J Med Med Sci. 2002 Dec;31(4):361-5. To Reference
Ref 3The fenfluramine metabolite (+)-norfenfluramine is vasoactive. J Pharmacol Exp Ther. 2004 May;309(2):845-52. Epub 2004 Jan 29. To Reference
Ref 4p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Eur J Pharmacol. 1998 Oct 23;359(2-3):185-90. To Reference



 

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Professor in Department of Pharmacy
National University of Singapore, Singapore


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