Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC000953

Drug Information

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CAS NumberCAS 118427-55-7
PubChem Compound IDCID 105049.    
PubChem Substance IDSID 682528.    
Target5-lipoxygenase activating proteinInhibitor[1][2]
Arachidonate 5-lipoxygenaseInhibitor[3][4][5]
Prostaglandin G/H synthase 2Inhibitor[6]
Ref 15-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D(3)-induced monocytic differentiation by activating p38 MAPK pathway. Mol Cell Biochem. 2009 May 5. [Epub ahead of print] To Reference
Ref 2Staphylococcus aureus alpha-toxin and Escherichia coli hemolysin impair cardiac regional perfusion and contractile function by activating myocardial eicosanoid metabolism in isolated rat hearts. Crit Care Med. 2009 Jun;37(6):2025-32. To Reference
Ref 35-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem. 2008 Feb;104(4):1091-100. Epub 2007 Nov 17. To Reference
Ref 4A genomic response of H-358 bronchiolar carcinoma cells to MK 886, an inhibitor of 5-lipoxygenase, assessed with a cDNA array. Anticancer Res. 2000 Jul-Aug;20(4):2433-9. To Reference
Ref 5Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. To Reference
Ref 6The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. J Cancer Res Clin Oncol. 2002 Oct;128(10):525-32. Epub 2002 Aug 29. To Reference


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