Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DNC003512

Drug Information
NameLY-294002    
Structure

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TargetSerine/threonine-protein kinase PLK1Inhibitor[1]
Serine/threonine-protein kinase Sgk1Inhibitor[2]
FK506 binding protein 12Inhibitor[3]
MAP kinase ERK2Inhibitor[2]
MAP kinase p38 betaInhibitor[2]
PI3-kinase p110-beta subunitInhibitor[4]
PI3-kinase p110-gamma subunitInhibitor[5]
Serine/threonine-protein kinase Chk1 Inhibitor[2]
Serine/threonine-protein kinase AKTInhibitor[2]
Ribosomal protein S6 kinase alpha 5Inhibitor[2]
Rho-associated protein kinase 2Inhibitor[2]
Protein kinase C alpha Inhibitor[2]
PI3-kinase p110-delta subunitInhibitor[6]
MAP kinase p38 gammaInhibitor[2]
MAP kinase p38 alphaInhibitor[2]
Glycogen synthase kinase-3 betaInhibitor[2]
DNA-dependent protein kinaseInhibitor[7]
Tyrosine-protein kinase LCKInhibitor[2]
c-Jun N-terminal kinase 1Inhibitor[2]
Ref 1Biochem J. 2007 Dec 15;408(3):297-315.The selectivity of protein kinase inhibitors: a further update. To Reference
Ref 2Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 3J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. To Reference
Ref 4Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. Epub 2009 Aug 29.Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening. To Reference
Ref 5Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. Epub 2007 Jun 6.Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. To Reference
Ref 6J Med Chem. 2006 Jun 29;49(13):3857-71.Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. To Reference
Ref 7J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. To Reference



 

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Professor in Department of Pharmacy
National University of Singapore, Singapore


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