Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC003591

Drug Information

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TargetAlpha-1a adrenergic receptorInhibitor[1]
Dopamine D2 receptorInhibitor[2]
Dopamine D3 receptorInhibitor[3]
Dopamine D4 receptorInhibitor[3]
Serotonin 1a (5-HT1a) receptorInhibitor[4]
Serotonin 2a (5-HT2a) receptorInhibitor[5]
Serotonin 6 (5-HT6) receptorInhibitor[6]
Serotonin 7 (5-HT7) receptorInhibitor[6]
Ref 1Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. To Reference
Ref 2J Med Chem. 2005 Jan 13;48(1):266-73.Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. To Reference
Ref 3J Med Chem. 2005 Feb 10;48(3):694-709.Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. To Reference
Ref 4J Med Chem. 1993 Oct 15;36(21):3161-5.Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. To Reference
Ref 5J Nat Prod. 1997 Jun;60(6):651-3.Activity of Parthenolide at 5HT2A receptors. To Reference
Ref 6J Med Chem. 2003 Jul 3;46(14):2795-812.Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). To Reference


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