Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DNC003726

Drug Information
NameSB-203580    
SynonymsSB-203580    
Structure

Click to save drug structure in 3D MOL format

Click to save drug structure in 2D MOL format
   
TargetArachidonate 5-lipoxygenaseInhibitor[1]
Cytochrome P450 2D6Inhibitor[2]
Cytochrome P450 3A4Inhibitor[2]
Glycogen synthase kinase-3 betaInhibitor[3]
MAP kinase p38 alphaInhibitor[4]
MAP kinase p38 betaInhibitor[5]
MAP kinase p38 gammaInhibitor[3]
Mitogen-activated protein kinase 1Inhibitor[6]
Protein kinase C alpha Inhibitor[3]
Rho-associated protein kinase 2Inhibitor[3]
Ribosomal protein S6 kinase alpha 5Inhibitor[3]
Serine/threonine-protein kinase AKTInhibitor[3]
Serine/threonine-protein kinase Chk1 Inhibitor[3]
Serine/threonine-protein kinase RAFInhibitor[5]
Serine/threonine-protein kinase RIPK2Inhibitor[7]
Serine/threonine-protein kinase Sgk1Inhibitor[3]
TNF-alphaInhibitor[8]
Tyrosine-protein kinase LCKInhibitor[5]
Tyrosine-protein kinase SRCInhibitor[7]
c-Jun N-terminal kinase 1Inhibitor[3]
c-Jun N-terminal kinase 2Inhibitor[7]
c-Jun N-terminal kinase 3Inhibitor[5]
Ref 1Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995) To Reference
Ref 2J Med Chem. 2004 Dec 2;47(25):6311-25.Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position. To Reference
Ref 3Biochem J. 2000 Oct 1;351(Pt 1):95-105.Specificity and mechanism of action of some commonly used protein kinase inhibitors. To Reference
Ref 4Bioorg Med Chem. 2010 Mar 15;18(6):2204-18. Epub 2010 Feb 8.In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. To Reference
Ref 5J Med Chem. 2008 Jul 24;51(14):4122-49. Epub 2008 Jun 26.Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. To Reference
Ref 6Antimicrob Agents Chemother. 2007 Dec;51(12):4324-8. Epub 2007 Oct 8.Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection. To Reference
Ref 7J Med Chem. 2005 Jun 16;48(12):4138-52.Rapid computational identification of the targets of protein kinase inhibitors. To Reference
Ref 8J Med Chem. 2005 Jan 27;48(2):414-26.Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation. To Reference



 

Welcome to sign our Guestbook.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhu.


Dr. Chen Yuzong
Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

 
   
           
 
Computer-aided Drug Design
About BIDD | Databases | Software | Teaching | Research |  Links

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543