Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DNC003945

Drug Information
NameLY-293646    
Structure

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TargetDNA-dependent protein kinaseInhibitor[1]
FK506 binding protein 12Inhibitor[2]
PI3-kinase p110-beta subunitInhibitor[3]
PI3-kinase p110-delta subunitInhibitor[3]
PI3-kinase p110-gamma subunitInhibitor[3]
Ref 1J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. To Reference
Ref 2J Med Chem. 2005 Jan 27;48(2):569-85.Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro. To Reference
Ref 3Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13.LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. To Reference



 

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