Therapeutic Targets Database
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TTD Drug ID: DNC004166

Drug Information
NameISOCLOZAPINE    
SynonymsISOCLOZAPINE    
Structure

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TargetSerotonin 2a (5-HT2a) receptorInhibitor[1]
Alpha-1a adrenergic receptorInhibitor[1]
Alpha-1b adrenergic receptorInhibitor[1]
Alpha-1d adrenergic receptorInhibitor[1]
Dopamine D1 receptorInhibitor[1]
Dopamine D2 receptorInhibitor[1]
Dopamine D3 receptorInhibitor[2]
Dopamine D4 receptorInhibitor[2]
Dopamine D5 receptorInhibitor[2]
Muscarinic acetylcholine receptor M1Inhibitor[3]
Muscarinic acetylcholine receptor M2Inhibitor[3]
Muscarinic acetylcholine receptor M3Inhibitor[3]
Muscarinic acetylcholine receptor M4Inhibitor[3]
Muscarinic acetylcholine receptor M5Inhibitor[3]
Ref 1J Med Chem. 1997 Dec 5;40(25):4146-53.Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. To Reference
Ref 2J Med Chem. 1982 Jul;25(7):855-8.Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. To Reference
Ref 3J Med Chem. 1990 Feb;33(2):809-14.Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. To Reference



 

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