TTD Drug ID: DNC004426

Drug Information
Name	N-DESMETHYLCLOZAPINE
Synonyms	N-DESMETHYLCLOZAPINE
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
Target	HERG			Inhibitor	[1]
	Muscarinic acetylcholine receptor M2			Inhibitor	[2]
	Muscarinic acetylcholine receptor M3			Inhibitor	[2]
	Muscarinic acetylcholine receptor M4			Inhibitor	[2]
	Muscarinic acetylcholine receptor M5			Inhibitor	[2]
Ref 1	J Med Chem. 2009 Jul 23;52(14):4266-76.Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. To Reference
Ref 2	J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. To Reference

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Professor in Department of Pharmacy
National University of Singapore, Singapore

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