Therapeutic Targets Database
BIDD Pharmainformatics Databases
 
   
 

 

TTD Drug ID: DNC004664

Drug Information
NameA-80426    
Structure

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TargetAlpha-2c adrenergic receptorInhibitor[1]
Dopamine D2 receptorInhibitor[2]
Dopamine D4 receptorInhibitor[1]
Alpha-2a adrenergic receptorInhibitor[1]
Alpha-2b adrenergic receptorInhibitor[1]
Serotonin 1a (5-HT1a) receptorInhibitor[2]
Serotonin 2a (5-HT2a) receptorInhibitor[2]
Serotonin transporterInhibitor[3]
Serotonin transporterInhibitor[3]
Ref 1J Med Chem. 2005 Mar 24;48(6):2054-71.Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity. To Reference
Ref 2J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm. To Reference
Ref 3J Med Chem. 1997 Mar 28;40(7):1049-62.Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT uptake inhibiting and alpha2-antagonistic activities. To Reference



 

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