TTD Drug ID: DNC004714

Drug Information
Name	APIGENIN
Synonyms	APIGENIN
Structure	Click to save drug structure in 3D MOL format Click to save drug structure in 2D MOL format
Target	Aldose reductase			Inhibitor	[1]
	Androgen Receptor			Inhibitor	[2]
	Casein kinase II alpha			Inhibitor	[3]
	Cyclin-dependent kinase 6			Inhibitor	[4]
	Cytochrome P450 19A1			Inhibitor	[5]
	Cytochrome P450 1B1			Inhibitor	[6]
	Estradiol 17-beta-dehydrogenase 1			Inhibitor	[7]
	Protein kinase Pfmrk			Inhibitor	[8]
	Sialidase			Inhibitor	[9]
Ref 1	J Nat Prod. 2008 Apr;71(4):713-5. Epub 2008 Feb 26.Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. To Reference
Ref 2	Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. Epub 2009 Jun 23.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. To Reference
Ref 3	Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. Epub 2009 Apr 22.Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. To Reference
Ref 4	J Med Chem. 2005 Feb 10;48(3):737-43.Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. To Reference
Ref 5	Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. Epub 2010 Apr 8.Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). To Reference
Ref 6	Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. Epub 2010 Jul 13.Selective inhibition of methoxyflavonoids on human CYP1B1 activity. To Reference
Ref 7	J Med Chem. 2008 Jul 24;51(14):4188-99. Epub 2008 Jun 6.Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. To Reference
Ref 8	J Med Chem. 2004 Oct 21;47(22):5418-26.A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. To Reference
Ref 9	Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. Epub 2009 Aug 21.Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. To Reference

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