Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC004906

Drug Information

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TargetCytochrome P450 2D6Inhibitor[1]
Delta opioid receptorInhibitor[1]
Kappa opioid receptorInhibitor[2]
Mu opioid receptorInhibitor[3]
Urotensin II receptorInhibitor[4]
Ref 1Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52.Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. To Reference
Ref 2J Med Chem. 1996 Apr 12;39(8):1729-35.Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells. To Reference
Ref 3J Med Chem. 1994 Sep 2;37(18):2856-64.Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide. To Reference
Ref 4Bioorg Med Chem Lett. 2008 Jul 1;18(13):3716-9. Epub 2008 May 20.Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. To Reference


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