Therapeutic Targets Database
BIDD Pharmainformatics Databases


TTD Drug ID: DNC005570

Drug Information

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TargetAlpha-1a adrenergic receptorInhibitor[1]
Alpha-1a adrenergic receptorInhibitor[1]
Alpha-2a adrenergic receptorInhibitor[1]
Dopamine D1 receptorInhibitor[2]
Dopamine D2 receptorInhibitor[2]
Dopamine D3 receptorInhibitor[3]
Dopamine D4 receptorInhibitor[4]
Serotonin 1a (5-HT1a) receptorInhibitor[1]
Serotonin 2b (5-HT2b) receptorInhibitor[5]
Ref 1J Med Chem. 2003 Aug 28;46(18):3822-39.Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors. To Reference
Ref 2Bioorg Med Chem Lett. 2004 Dec 6;14(23):5813-6.Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands. To Reference
Ref 3Bioorg Med Chem Lett. 2010 Sep 1;20(17):5199-202. Epub 2010 Jul 6.Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha2A, D4.2, D3 and D2L receptors. To Reference
Ref 4J Med Chem. 2005 May 5;48(9):3171-81.Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands. To Reference
Ref 5J Med Chem. 2010 Nov 11;53(21):7573-86.Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs. To Reference


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